SCOPe 2.03: Domain d1pwaa_: 1pwa A:

Lineage for d1pwaa_ (1pwa A:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.42: beta-Trefoil [50352] (8 superfamilies)
   barrel, closed; n=6, S=12; and a hairpin triplet; meander
   duplication: has internal pseudo threefold symmetry

4. Superfamily b.42.1: Cytokine [50353] (3 families)

5. Family b.42.1.1: Fibroblast growth factors (FGF) [50354] (10 proteins)

6. Protein Fibroblast growth factor-19 (FGF19) [101778] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101779] (2 PDB entries)

8. Domain d1pwaa_: 1pwa A: [95211]
   complexed with gol, so4, trs

Details for d1pwaa_

PDB Entry: 1pwa, 1.3 Å

PDB Description: Crystal structure of Fibroblast Growth Factor 19

PDB Compounds: (A:) Fibroblast growth factor-19

SCOPe Domain Sequences for d1pwaa_:

Sequence, based on SEQRES records:

>d1pwaa_ b.42.1.1 (A:) Fibroblast growth factor-19 (FGF19) {Human (Homo sapiens) [TaxId: 9606]}
pirlrhlytsgphglsscflriradgvvdcargqsahslleikavalrtvaikgvhsvry
lcmgadgkmqgllqyseedcafeeeirpdgynvyrsekhrlpvslssakqrqlyknrgfl
plshflpmlpmvpeep

Sequence, based on observed residues (ATOM records):

>d1pwaa_ b.42.1.1 (A:) Fibroblast growth factor-19 (FGF19) {Human (Homo sapiens) [TaxId: 9606]}
pirlrhlytsgphglsscflriradgvvdcargqsahslleikavalrtvaikgvhsvry
lcmgadgkmqgllqyseedcafeeeirpdgynvyrsekhrlpvslslplshflpmlpmvp
eep

Timeline for d1pwaa_:

• d1pwaa_ first appeared in SCOP 1.67
  
• d1pwaa_ appears in SCOPe 2.02
  
• d1pwaa_ appears in SCOPe 2.04
  
• d1pwaa_ appears in the current release, SCOPe 2.08