Lineage for d1ozhc2 (1ozh C:7-186)

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 986456Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 986457Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 986458Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
  6. 986535Protein Catabolic acetolactate synthase [102328] (1 species)
  7. 986536Species Klebsiella pneumoniae [TaxId:573] [102329] (3 PDB entries)
  8. 986539Domain d1ozhc2: 1ozh C:7-186 [93840]
    Other proteins in same PDB: d1ozha1, d1ozha3, d1ozhb1, d1ozhb3, d1ozhc1, d1ozhc3, d1ozhd1, d1ozhd3
    complexed with he3, mg, peg, pge, po4

Details for d1ozhc2

PDB Entry: 1ozh (more details), 2 Å

PDB Description: The crystal structure of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate.
PDB Compounds: (C:) Acetolactate synthase, catabolic

SCOPe Domain Sequences for d1ozhc2:

Sequence, based on SEQRES records: (download)

>d1ozhc2 c.36.1.5 (C:7-186) Catabolic acetolactate synthase {Klebsiella pneumoniae [TaxId: 573]}
vrqwahgadlvvsqleaqgvrqvfgipgakidkvfdslldssiriipvrheanaafmaaa
vgritgkagvalvtsgpgcsnlitgmatansegdpvvalggavkradkakqvhqsmdtva
mfspvtkyaievtapdalaevvsnafraaeqgrpgsafvslpqdvvdgpvsgkvlpasga

Sequence, based on observed residues (ATOM records): (download)

>d1ozhc2 c.36.1.5 (C:7-186) Catabolic acetolactate synthase {Klebsiella pneumoniae [TaxId: 573]}
vrqwahgadlvvsqleaqgvrqvfgipgakidkvfdslldssiriipvrheanaafmaaa
vgritgkagvalvtsgpgcsnlitgmatansegdpvvalggavkradkakmdtvamfspv
tkyaievtapdalaevvsnafraaeqgrpgsafvslpqdvvdgpvsgkvlpasga

SCOPe Domain Coordinates for d1ozhc2:

Click to download the PDB-style file with coordinates for d1ozhc2.
(The format of our PDB-style files is described here.)

Timeline for d1ozhc2: