SCOPe 2.08: Domain d1osha1: 1osh A:248-475

Lineage for d1osha1 (1osh A:248-475)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Bile acid receptor FXR [101433] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101434] (8 PDB entries)

8. Domain d1osha1: 1osh A:248-475 [93496]
   Other proteins in same PDB: d1osha2
   complexed with fex

Details for d1osha1

PDB Entry: 1osh, 1.8 Å

PDB Description: A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

PDB Compounds: (A:) Bile acid receptor

SCOPe Domain Sequences for d1osha1:

Sequence, based on SEQRES records:

>d1osha1 a.123.1.1 (A:248-475) Bile acid receptor FXR {Human (Homo sapiens) [TaxId: 9606]}
eltpdqqtllhfimdsynkqrmpqeitnkilkeefsaeenfliltematnhvqvlveftk
klpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdlleerirnsgisdeyit
pmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckihq
penpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdv

Sequence, based on observed residues (ATOM records):

>d1osha1 a.123.1.1 (A:248-475) Bile acid receptor FXR {Human (Homo sapiens) [TaxId: 9606]}
eltpdqqtllhfimdsynkqrmpenfliltematnhvqvlveftkklpgfqtldhedqia
llkgsaveamflrsaeifnkklpsghsdlleerirnsgisdeyitpmfsfyksigelkmt
qeeyalltaivilspdrqyikdreaveklqeplldvlqklckihqpenpqhfacllgrlt
elrtfnhhhaemlmswrvndhkftpllceiwdv

Timeline for d1osha1:

• d1osha1 first appeared in SCOP 1.67, called d1osha_
  
• d1osha1 appears in SCOPe 2.07