Class c: Alpha and beta proteins (a/b) [51349] (121 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module |
Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [89652] (1 PDB entry) |
Domain d1ni4a_: 1ni4 A: [85728] Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2 |
Domain d1ni4c_: 1ni4 C: [85731] Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2 complexed with k, mg, mse, tpp; mutant |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase (PP module):