SCOP 1.65: Species: Human (Homo sapiens)

Lineage for Species: Human (Homo sapiens)

Root: SCOP 1.65
Class c: Alpha and beta proteins (a/b) [51349] (121 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)
Species Human (Homo sapiens) [TaxId:9606] [89652] (1 PDB entry)

PDB entry in Species: Human (Homo sapiens):

Domain(s) for 1ni4:
1. Domain d1ni4a_: 1ni4 A: [85728]
  Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2
2. Domain d1ni4c_: 1ni4 C: [85731]
  Other proteins in same PDB: d1ni4b1, d1ni4b2, d1ni4d1, d1ni4d2
  complexed with k, mg, mse, tpp; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase (PP module)

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase (PP module):

Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase (PP module) is new in SCOP 1.65
Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase (PP module) is called Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module) in SCOP 1.67
Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase (PP module) appears in the current release, SCOPe 2.08, called Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module)