Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108723Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 2108757Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)
  7. 2108758Species Human (Homo sapiens) [TaxId:9606] [89652] (7 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1ni4:
    1. 2108765Domain d1ni4a1: 1ni4 A:1-361 [85728]
      Other proteins in same PDB: d1ni4a2, d1ni4b1, d1ni4b2, d1ni4b3, d1ni4c2, d1ni4d1, d1ni4d2, d1ni4d3
      complexed with k, mg, tpp
    2. 2108766Domain d1ni4c1: 1ni4 C:1-361 [85731]
      Other proteins in same PDB: d1ni4a2, d1ni4b1, d1ni4b2, d1ni4b3, d1ni4c2, d1ni4d1, d1ni4d2, d1ni4d3
      complexed with k, mg, tpp
  2. Domain(s) for 2ozl:
    1. 2108763Domain d2ozla1: 2ozl A:1-361 [145744]
      Other proteins in same PDB: d2ozla2, d2ozlb1, d2ozlb2, d2ozlb3, d2ozlc3, d2ozld1, d2ozld2, d2ozld3
      complexed with k, mg, tpp
    2. 2108764Domain d2ozlc2: 2ozl C:1-361 [145745]
      Other proteins in same PDB: d2ozla2, d2ozlb1, d2ozlb2, d2ozlb3, d2ozlc3, d2ozld1, d2ozld2, d2ozld3
      automated match to d1ni4a_
      complexed with k, mg, tpp
  3. Domain(s) for 3exe:
    1. 2108759Domain d3exea1: 3exe A:1-361 [209698]
      Other proteins in same PDB: d3exea2, d3exeb1, d3exeb2, d3exec2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeg2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    2. 2108760Domain d3exec1: 3exe C:1-361 [209701]
      Other proteins in same PDB: d3exea2, d3exeb1, d3exeb2, d3exec2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeg2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    3. 2108761Domain d3exee_: 3exe E: [209704]
      Other proteins in same PDB: d3exea2, d3exeb1, d3exeb2, d3exec2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeg2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    4. 2108762Domain d3exeg1: 3exe G:1-361 [209707]
      Other proteins in same PDB: d3exea2, d3exeb1, d3exeb2, d3exec2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeg2, d3exeh1, d3exeh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
  4. Domain(s) for 3exf:
    1. 2108772Domain d3exfa1: 3exf A:1-361 [245928]
      Other proteins in same PDB: d3exfa2, d3exfb1, d3exfb2, d3exfc2, d3exfd1, d3exfd2, d3exfe2, d3exff1, d3exff2, d3exfg2, d3exfh1, d3exfh2
      automated match to d3exia_
      complexed with k, mg, tpp
    2. 2108773Domain d3exfc1: 3exf C:1-361 [245931]
      Other proteins in same PDB: d3exfa2, d3exfb1, d3exfb2, d3exfc2, d3exfd1, d3exfd2, d3exfe2, d3exff1, d3exff2, d3exfg2, d3exfh1, d3exfh2
      automated match to d3exia_
      complexed with k, mg, tpp
    3. 2108774Domain d3exfe1: 3exf E:1-361 [245934]
      Other proteins in same PDB: d3exfa2, d3exfb1, d3exfb2, d3exfc2, d3exfd1, d3exfd2, d3exfe2, d3exff1, d3exff2, d3exfg2, d3exfh1, d3exfh2
      automated match to d3exia_
      complexed with k, mg, tpp
    4. 2108775Domain d3exfg1: 3exf G:1-361 [245937]
      Other proteins in same PDB: d3exfa2, d3exfb1, d3exfb2, d3exfc2, d3exfd1, d3exfd2, d3exfe2, d3exff1, d3exff2, d3exfg2, d3exfh1, d3exfh2
      automated match to d3exia_
      complexed with k, mg, tpp
  5. Domain(s) for 3exg:
    1. 2108776Domain d3exg11: 3exg 1:1-361 [245940]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    2. 2108777Domain d3exg31: 3exg 3:1-361 [245943]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    3. 2108778Domain d3exg51: 3exg 5:1-361 [245946]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    4. 2108779Domain d3exga1: 3exg A:1-361 [245949]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    5. 2108780Domain d3exgc1: 3exg C:1-361 [245952]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    6. 2108781Domain d3exge1: 3exg E:1-361 [245955]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    7. 2108782Domain d3exgg1: 3exg G:1-361 [245958]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    8. 2108783Domain d3exgi1: 3exg I:1-361 [245961]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    9. 2108784Domain d3exgk1: 3exg K:1-361 [245964]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    10. 2108785Domain d3exgm1: 3exg M:1-361 [245967]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    11. 2108786Domain d3exgo1: 3exg O:1-361 [245970]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    12. 2108787Domain d3exgq1: 3exg Q:1-361 [245973]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    13. 2108788Domain d3exgs_: 3exg S: [245976]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    14. 2108789Domain d3exgu1: 3exg U:1-361 [245979]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    15. 2108790Domain d3exgw1: 3exg W:1-361 [245982]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
    16. 2108791Domain d3exgy1: 3exg Y:1-361 [245985]
      Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
      automated match to d3exia_
      complexed with k
  6. Domain(s) for 3exh:
    1. 2108768Domain d3exha1: 3exh A:1-361 [209710]
      Other proteins in same PDB: d3exha2, d3exhb1, d3exhb2, d3exhc2, d3exhd1, d3exhd2, d3exhe2, d3exhf1, d3exhf2, d3exhg2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    2. 2108769Domain d3exhc1: 3exh C:1-361 [209713]
      Other proteins in same PDB: d3exha2, d3exhb1, d3exhb2, d3exhc2, d3exhd1, d3exhd2, d3exhe2, d3exhf1, d3exhf2, d3exhg2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    3. 2108770Domain d3exhe1: 3exh E:1-361 [209716]
      Other proteins in same PDB: d3exha2, d3exhb1, d3exhb2, d3exhc2, d3exhd1, d3exhd2, d3exhe2, d3exhf1, d3exhf2, d3exhg2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
    4. 2108771Domain d3exhg1: 3exh G:1-361 [209719]
      Other proteins in same PDB: d3exha2, d3exhb1, d3exhb2, d3exhc2, d3exhd1, d3exhd2, d3exhe2, d3exhf1, d3exhf2, d3exhg2, d3exhh1, d3exhh2
      automated match to d1ni4a_
      complexed with gol, k, mn, tpp
  7. Domain(s) for 3exi:

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module)

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 E1-beta subunit of pyruvate dehydrogenase (PP module):