SCOP 1.71: Domain d1nysd_: 1nys D:

Lineage for d1nysd_ (1nys D:)

1. Root: SCOP 1.71

2. Class g: Small proteins [56992] (79 folds)

3. Fold g.17: Cystine-knot cytokines [57500] (1 superfamily)
   disulfide-rich fold; common core is all-beta

4. Superfamily g.17.1: Cystine-knot cytokines [57501] (7 families)

5. Family g.17.1.2: Transforming growth factor (TGF)-beta [57507] (7 proteins)

6. Protein Activin A (Inhibin beta A) [90170] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [90171] (3 PDB entries)

8. Domain d1nysd_: 1nys D: [86416]
   Other proteins in same PDB: d1nysa_, d1nysc_
   complexed with the extracellular domain of activin type II receptor

Details for d1nysd_

PDB Entry: 1nys, 3.05 Å

PDB Description: crystal structure of activin a bound to the ecd of actriib p41

SCOP Domain Sequences for d1nysd_:

Sequence, based on SEQRES records:

>d1nysd_ g.17.1.2 (D:) Activin A (Inhibin beta A) {Human (Homo sapiens)}
icckkqffvsfkdigwndwiiapsgyhanycegecpshiagtsgsslsfhstvinhyrmr
ghspfanlksccvptklrpmsmlyyddgqniikkdiqnmiveecgcs

Sequence, based on observed residues (ATOM records):

>d1nysd_ g.17.1.2 (D:) Activin A (Inhibin beta A) {Human (Homo sapiens)}
icckkqffvsfkdiwndwiiapsgyhanycgecpslksccvptklrpmsmlyyddgqnii
kkdiqnmiveecgcs

Timeline for d1nysd_:

• d1nysd_ first appeared in SCOP 1.65
  
• d1nysd_ appears in SCOP 1.69
  
• d1nysd_ appears in SCOP 1.73
  
• d1nysd_ appears in the current release, SCOPe 2.08