SCOP 1.69: Domain d1nowa1: 1now A:200-552

Lineage for d1nowa1 (1now A:200-552)

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (31 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (11 families)

5. Family c.1.8.6: beta-N-acetylhexosaminidase catalytic domain [51550] (3 proteins)
   Glycosyl hydrolase family 20, GH20

6. Protein beta-hexosaminidase B [89486] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89487] (4 PDB entries)

8. Domain d1nowa1: 1now A:200-552 [85936]
   Other proteins in same PDB: d1nowa2, d1nowb2

Details for d1nowa1

PDB Entry: 1now, 2.2 Å

PDB Description: human lysosomal beta-hexosaminidase isoform b in complex with (2r,3r, 4s,5r)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidinium chloride (galnac-isofagomine)

SCOP Domain Sequences for d1nowa1:

Sequence, based on SEQRES records:

>d1nowa1 c.1.8.6 (A:200-552) beta-hexosaminidase B {Human (Homo sapiens)}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysrqnkldsf
gpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtd
fkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtas
gfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnlt
prlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Sequence, based on observed residues (ATOM records):

>d1nowa1 c.1.8.6 (A:200-552) beta-hexosaminidase B {Human (Homo sapiens)}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysldsfgpin
ptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkkl
esfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpv
ilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlw
prasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Timeline for d1nowa1:

• d1nowa1 first appeared in SCOP 1.65
  
• d1nowa1 appears in SCOP 1.67
  
• d1nowa1 appears in SCOP 1.71
  
• d1nowa1 appears in the current release, SCOPe 2.08