SCOPe 2.06: Domain d1j3kc_: 1j3k C:

Lineage for d1j3kc_ (1j3k C:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88964] (3 PDB entries)

8. Domain d1j3kc_: 1j3k C: [84072]
   Other proteins in same PDB: d1j3ka_, d1j3kb_
   complexed with ndp, ump, wra; mutant

Details for d1j3kc_

PDB Entry: 1j3k, 2.1 Å

PDB Description: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with wr99210, nadph, and dump

PDB Compounds: (C:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d1j3kc_:

Sequence; same for both SEQRES and ATOM records:

>d1j3kc_ d.117.1.1 (C:) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
ddeeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngnkq
sdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnknvr
iweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinl
ikndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpfni
asysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdikn
iedftisdftiqnyvhhekismdmaa

Timeline for d1j3kc_:

• d1j3kc_ first appeared in SCOP 1.65
  
• d1j3kc_ appears in SCOPe 2.05
  
• d1j3kc_ appears in SCOPe 2.07
  
• d1j3kc_ appears in the current release, SCOPe 2.08