Lineage for Family b.1.18.2: E-set domains of sugar-utilizing enzymes

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2032114Superfamily b.1.18: E set domains [81296] (24 families) (S)
    "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies
  5. 2032237Family b.1.18.2: E-set domains of sugar-utilizing enzymes [81282] (20 protein domains)
    domains of unknown function associated with different type of catalytic domains in a different sequential location
    subgroup of the larger IPT/TIG domain family

Protein Domains:

  1. 20322381,4-alpha-glucan branching enzyme, N-terminal domain N [81962] (1 species)
    domain architecture similar to isoamylase
  2. 2032244Bacterial chitobiase (N-acetyl-beta-glucoseaminidase), C-terminal domain [49211] (1 species)
    rudiment form of Ig-like domain; follows the catalytic (beta/alpha)8-barrel domain; family 20 glycosyl hydrolases
  3. 2032250Beta-1,4-mannanase domain 2 (postcatalytic) [141020] (1 species)
  4. 2032255CelD cellulase, N-terminal domain [49231] (1 species)
    precedes the catalytic alpha6/alpha6 domain
  5. 2032258Cellulose 1,4-beta-cellobiosidase CbhA, precatalytic domain [101521] (1 species)
  6. 2032262Chitin-binding protein CBP21 [117045] (1 species)
    member of Pfam PF03067; elaborated fold with a large insertion between strands A and A'
  7. 2032270Chitinase A, N-terminal domain N [49233] (1 species)
    precedes the catalytic (beta/alpha)8-barrel domain
  8. 2032283Cyclomaltodextrin glycanotransferase, domain D [49215] (4 species)
    follows the starch-binding domain C; the catalytic domain A has (beta/alpha)8-barrel fold; family 13 glycosyl hydrolases
    1. 2032284Species Bacillus circulans, different strains [TaxId:1397] [49216] (36 PDB entries)
    2. 2032325Species Bacillus sp., strain 1011 [TaxId:1409] [49219] (8 PDB entries)
      Uniprot P05618
    3. 2032342Species Bacillus stearothermophilus [TaxId:1422] [49217] (1 PDB entry)
    4. 2032344Species Thermoanaerobacterium thermosulfurigenes, EM1 [TaxId:33950] [49220] (4 PDB entries)
  9. 2032349Cyclomaltodextrinase, N-terminal domain [101523] (1 species)
    protein shares similar domain organization with maltogenic amylases but differs in the spatial arrangement of its domains
  10. 2032353Five domain "maltogenic" alpha-amylase (glucan 1,4-alpha-maltohydrolase), domain D [81280] (1 species)
    domain architecture similar to cyclomaltodextrin glycosylhydrolases
  11. 2032357Galactose oxidase, C-terminal domain [49209] (3 species)
    follows the catalytic seven-bladed beta-propeller domain
    1. 2032358Species Dactylium dendroides [TaxId:5132] [49210] (3 PDB entries)
      Uniprot Q01745 42-680
    2. 2032362Species Fungus (Fusarium sp.) [TaxId:29916] [69164] (2 PDB entries)
      sequence identical to that of Dactylium dendroides
    3. 2032365Species Fusarium graminearum (Gibberella zeae) [TaxId:5518] [158881] (6 PDB entries)
  12. 2032372Glucans biosynthesis protein G (MdoG, OpgG), C-terminal domain [110054] (1 species)
  13. 2032376Glucodextranase, domain B [101525] (1 species)
  14. 2032380Glycosyltrehalose trehalohydrolase, N-terminal domain N [49224] (2 species)
    domain architecture similar to isoamylase
    1. 2032381Species Deinococcus radiodurans [TaxId:1299] [141019] (9 PDB entries)
      Uniprot Q9RX51 14-110
    2. 2032391Species Sulfolobus solfataricus, km1 [TaxId:2287] [49225] (8 PDB entries)
  15. 2032400Hyaluronate lyase precatalytic domain [69167] (1 species)
    precedes the catalytic incomplete alpha5/alpha5 barrel
    a rudiment form of Ig-like domain
  16. 2032405Isoamylase, N-terminal domain N [49226] (1 species)
    elaborated with a few large insertions in the common fold
    precedes the catalytic (beta/alpha)8-barrel domain, the domain architecture similar to maltogenic amylases
  17. 2032408Maltogenic amylase, N-terminal domain N [49221] (4 species)
    precedes the catalytic (beta/alpha)8-barrel domain
    1. 2032409Species Bacillus sp., cyclomaltodextrinase [TaxId:1409] [74842] (1 PDB entry)
    2. 2032412Species Thermoactinomyces vulgaris, TVAI [TaxId:2026] [74843] (8 PDB entries)
    3. 2032422Species Thermoactinomyces vulgaris, TVAII [TaxId:2026] [49223] (12 PDB entries)
    4. 2032447Species Thermus sp. [TaxId:275] [49222] (2 PDB entries)
  18. 2032452Neopullulanase, N-terminal domain [81960] (1 species)
    homologous to maltogenic amylase
  19. 2032462Pullulanase PulA [158883] (1 species)
    contains two E-set domains in tandem
  20. 2032476Sialidase, "linker" domain [49237] (1 species)
    follows the catalytic six-bladed beta-propeller domain

More info for Family b.1.18.2: E-set domains of sugar-utilizing enzymes

Timeline for Family b.1.18.2: E-set domains of sugar-utilizing enzymes: