SCOP 1.67: Domain d1mf8a_: 1mf8 A:

Lineage for d1mf8a_ (1mf8 A:)

1. Root: SCOP 1.67

2. Class d: Alpha and beta proteins (a+b) [53931] (260 folds)

3. Fold d.159: Metallo-dependent phosphatases [56299] (1 superfamily)
   4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication

4. Superfamily d.159.1: Metallo-dependent phosphatases [56300] (6 families)

5. Family d.159.1.3: Protein serine/threonine phosphatase [56310] (3 proteins)

6. Protein Protein phosphatase-2B (PP-2B, calcineurin A subunit) [56313] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56315] (3 PDB entries)

8. Domain d1mf8a_: 1mf8 A: [79040]
   Other proteins in same PDB: d1mf8b_, d1mf8c_
   complexed with aba, bmt, ca, dal, mle, mva, po4, sar

Details for d1mf8a_

PDB Entry: 1mf8, 3.1 Å

PDB Description: Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin

SCOP Domain Sequences for d1mf8a_:

Sequence; same for both SEQRES and ATOM records:

>d1mf8a_ d.159.1.3 (A:) Protein phosphatase-2B (PP-2B, calcineurin A subunit) {Human (Homo sapiens)}
avpfppshrltakevfdndgkprvdilkahlmkegrleesvalriitegasilrqeknll
didapvtvcgdihgqffdlmklfevggspantrylflgdyvdrgyfsiecvlylwalkil
ypktlfllrgnhecrhlteyftfkqeckikyservydacmdafdclplaalmnqqflcvh
gglspeintlddirkldrfkeppaygpmcdilwsdpledfgnektqehfthntvrgcsyf
ysypavceflqhnnllsilraheaqdagyrmyrksqttgfpslitifsapnyldvynnka
avlkyennvmnirqfncsphpywlpnfmdvftwslpfvgekvtemlvnvlni

Timeline for d1mf8a_:

• d1mf8a_ first appeared in SCOP 1.63
  
• d1mf8a_ appears in SCOP 1.65
  
• d1mf8a_ appears in SCOP 1.69
  
• d1mf8a_ appears in the current release, SCOPe 2.08