SCOPe 2.04: Domain d1lxcb_: 1lxc B:

Lineage for d1lxcb_ (1lxc B:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Enoyl-ACP reductase [51791] (11 species)

7. Species Escherichia coli [TaxId:562] [51794] (13 PDB entries)

8. Domain d1lxcb_: 1lxc B: [78290]
   complexed with aym, nad

Details for d1lxcb_

PDB Entry: 1lxc, 2.4 Å

PDB Description: Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor

PDB Compounds: (B:) Enoyl-[acyl-carrier-protein] reductase [NADH]

SCOPe Domain Sequences for d1lxcb_:

Sequence, based on SEQRES records:

>d1lxcb_ c.2.1.2 (B:) Enoyl-ACP reductase {Escherichia coli [TaxId: 562]}
gflsgkrilvtgvasklsiaygiaqamhregaelaftyqndklkgrveefaaqlgsdivl
qcdvaedasidtmfaelgkvwpkfdgfvhsigfapgdqldgdyvnavtregfkiahdiss
ysfvamakacrsmlnpgsalltlsylgaeraipnynvmglakasleanvrymanamgpeg
vrvnaisagpirtlaasgikdfrkmlahceavtpirrtvtiedvgnsaaflcsdlsagis
gevvhvdggfsiaamnel

Sequence, based on observed residues (ATOM records):

>d1lxcb_ c.2.1.2 (B:) Enoyl-ACP reductase {Escherichia coli [TaxId: 562]}
gflsgkrilvtgvasklsiaygiaqamhregaelaftyqndklkgrveefaaqlgsdivl
qcdvaedasidtmfaelgkvwpkfdgfvhsigfapgdqldgdyvnavtregfkiahdiss
ysfvamakacrsmlnpgsalltlsylgaeraipnynvmglakasleanvrymanamgpeg
vrvnaisagpirtlfrkmlahceavtpirrtvtiedvgnsaaflcsdlsagisgevvhvd
ggfsiaamnel

Timeline for d1lxcb_:

• d1lxcb_ first appeared in SCOP 1.63
  
• d1lxcb_ appears in SCOPe 2.03
  
• d1lxcb_ appears in SCOPe 2.05
  
• d1lxcb_ appears in the current release, SCOPe 2.08