SCOP 1.69: Domain d1gwqa_: 1gwq A:

Lineage for d1gwqa_ (1gwq A:)

1. Root: SCOP 1.69

2. Class a: All alpha proteins [46456] (218 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (30 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (14 PDB entries)

8. Domain d1gwqa_: 1gwq A: [76366]

Details for d1gwqa_

PDB Entry: 1gwq, 2.45 Å

PDB Description: human oestrogen receptor alpha ligand-binding domain in complex with raloxifene core and tif2 nrbox2 peptide

SCOP Domain Sequences for d1gwqa_:

Sequence, based on SEQRES records:

>d1gwqa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens)}
skknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminw
akrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcveg
mveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvld
kitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydll
lemldahr

Sequence, based on observed residues (ATOM records):

>d1gwqa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens)}
skknslalsltadqmvsalldaeppilysepfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydlllemld
ahr

Timeline for d1gwqa_:

• d1gwqa_ first appeared in SCOP 1.63
  
• d1gwqa_ appears in SCOP 1.67
  
• d1gwqa_ appears in SCOP 1.71
  
• d1gwqa_ appears in the current release, SCOPe 2.08