SCOPe 2.04: Domain d1ly4a_: 1ly4 A:

Lineage for d1ly4a_ (1ly4 A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (23 PDB entries)

8. Domain d1ly4a_: 1ly4 A: [74338]
   complexed with coq, nap

Details for d1ly4a_

PDB Entry: 1ly4, 2.1 Å

PDB Description: analysis of quinazoline and pyrido[2,3d]pyrimidine n9-c10 reversed bridge antifolates in complex with nadp+ and pneumocystis carinii dihydrofolate reductase

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1ly4a_:

Sequence; same for both SEQRES and ATOM records:

>d1ly4a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Fungus (Pneumocystis carinii) [TaxId: 4754]}
nqqksltlivalttsygigrsnslpwklkkeisyfkrvtsfvptfdsfesmnvvlmgrkt
wesiplqfrplkgrinvvitrnesldlgngihsaksldhalellyrtygsessvqinrif
viggaqlykaamdhpkldrimatiiykdihcdvffplkfrdkewssvwkkekhsdleswv
gtkvphgkinedgfdyefemwtrdl

Timeline for d1ly4a_:

• d1ly4a_ first appeared in SCOP 1.61
  
• d1ly4a_ appears in SCOPe 2.03
  
• d1ly4a_ appears in SCOPe 2.05
  
• d1ly4a_ appears in the current release, SCOPe 2.08