SCOP 1.71: Domain d1jvnb1: 1jvn B:230-552

Lineage for d1jvnb1 (1jvn B:230-552)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (5 families)

5. Family c.1.2.1: Histidine biosynthesis enzymes [51367] (2 proteins)
   structural evidence for the gene duplication within the barrel fold

6. Protein Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF [51370] (4 species)

7. Species Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId:4932] [69379] (4 PDB entries)

8. Domain d1jvnb1: 1jvn B:230-552 [67357]
   Other proteins in same PDB: d1jvna2, d1jvnb2
   complexed with 143, ni, pop, so4

Details for d1jvnb1

PDB Entry: 1jvn, 2.1 Å

PDB Description: crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (beta/alpha)8 barrel joins two active sites

SCOP Domain Sequences for d1jvnb1:

Sequence, based on SEQRES records:

>d1jvnb1 c.1.2.1 (B:230-552) Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF {Baker's yeast (Saccharomyces cerevisiae), His7}
dysnygltrriiacldvrtndqgdlvvtkgdqydvreksdgkgvrnlgkpvqlaqkyyqq
gadevtflnitsfrdcplkdtpmlevlkqaaktvfvpltvgggikdivdvdgtkipalev
aslyfrsgadkvsigtdavyaaekyyelgnrgdgtspietiskaygaqavvisvdpkrvy
vnsqadtknkvfeteypgpngekycwyqctikggresrdlgvweltracealgageilln
cidkdgsnsgydleliehvkdavkipviassgagvpehfeeaflktradaclgagmfhrg
eftvndvkeyllehglkvrmdee

Sequence, based on observed residues (ATOM records):

>d1jvnb1 c.1.2.1 (B:230-552) Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF {Baker's yeast (Saccharomyces cerevisiae), His7}
dysnygltrriiacldvrtndqgdlvvtkgdlgkpvqlaqkyyqqgadevtflnitdcpl
kdtpmlevlkqaaktvfvpltvgggikdivdvdgtkipalevaslyfrsgadkvsigtda
vyaaekyyelgnrgdgtspietiskaygaqavvisvdpkrvyvnsqadtknkvfeteypg
pngekycwyqctikggresrdlgvweltracealgageillncidkdgsnsgydlelieh
vkdavkipviassgagvpehfeeaflktradaclgagmfhrgeftvndvkeyllehglkv
rmdee

Timeline for d1jvnb1:

• d1jvnb1 first appeared in SCOP 1.59
  
• d1jvnb1 appears in SCOP 1.69
  
• d1jvnb1 appears in SCOP 1.73
  
• d1jvnb1 appears in the current release, SCOPe 2.08