SCOPe 2.04: Domain d1hw9b2: 1hw9 B:463-586,B:704-860

Lineage for d1hw9b2 (1hw9 B:463-586,B:704-860)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
   unusual fold

4. Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family)

5. Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)

6. Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56545] (9 PDB entries)

8. Domain d1hw9b2: 1hw9 B:463-586,B:704-860 [61309]
   Other proteins in same PDB: d1hw9a1, d1hw9b1, d1hw9c1, d1hw9d1
   complexed with adp, sim

Details for d1hw9b2

PDB Entry: 1hw9, 2.33 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with simvastatin

PDB Compounds: (B:) hmg-coa reductase

SCOPe Domain Sequences for d1hw9b2:

Sequence; same for both SEQRES and ATOM records:

>d1hw9b2 d.179.1.1 (B:463-586,B:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladXksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivt
aiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqacl
qmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

Timeline for d1hw9b2:

• d1hw9b2 first appeared in SCOP 1.57
  
• d1hw9b2 appears in SCOPe 2.03
  
• d1hw9b2 appears in SCOPe 2.05
  
• d1hw9b2 appears in the current release, SCOPe 2.08