SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Class k: Designed proteins

  1. Root: SCOPe 2.06
  2. 2245226Class k: Designed proteins [58788] (44 folds)

Folds:

  1. 2245227k.1: Hybrid and chimeric proteins [58789] (1 superfamily)
  2. k.2: Amphiphilic (amphipathic) alpha helix [58798] (1 superfamily)
  3. 2245268k.3: Collagen-like peptides [58805] (1 superfamily)
  4. 2245331k.4: Coiled serine [58812] (1 superfamily)
  5. 2245341k.6: Designed heterodimeric coiled-coil [58822] (1 superfamily)
  6. 2245354k.7: Thermostable heterotrimeric coiled coil [58827] (1 superfamily)
  7. 2245362k.8: Designed four-helix bundle protein [58832] (1 superfamily)
  8. 2245425k.9: Designed single chain three-helix bundle [58839] (1 superfamily)
    not a true fold: both possible topologies are created
  9. k.10: Peptide f (amphiphilic octadecapeptide) [58846] (1 superfamily)
  10. 2245444k.11: Retro-GCN4 leucine zipper [58851] (1 superfamily)
  11. 2245451k.12: Zinc finger design [58856] (1 superfamily)
  12. 2245483k.13: Protein A Ig(Fc)-binding domain mimics [58863] (1 superfamily)
  13. 2245497k.14: Zinc finger based beta-beta-alpha motif [58868] (1 superfamily)
  14. 2245525k.15: helix-turn-helix motif [58877] (1 superfamily)
  15. 2245534k.16: alpha2d [58882] (1 superfamily)
  16. 2245541k.17: Right-handed coiled coil [58887] (1 superfamily)
  17. k.18: Erythropoietin (EPO) mimetic peptides [58892] (1 superfamily)
  18. 2245562k.19: IL-1 receptor type 1 antagonist peptide AF10847 [58897] (1 superfamily)
  19. k.20: Octreotide (Sandostatine), a somatostatine analogue [58902] (1 superfamily)
  20. 2245575k.21: Calmodulin [58907] (1 superfamily)
  21. 2245584k.22: WW domain-based designs [58912] (1 superfamily)
  22. 2245593k.23: Scorpion toxin-based designs [58917] (1 superfamily)
  23. k.24: Inhibitor of mammalian ribonucleotide reductase [58925] (1 superfamily)
  24. 2245617k.26: TH (toxin hand)-motif beta-sheet mini-protein designs [64673] (1 superfamily)
  25. k.27: Integrin-binding RGD peptide [64682] (1 superfamily)
  26. k.28: Peptide antagonists of IGF-1 [64687] (1 superfamily)
  27. 2245648k.29: beta-hairpin design [64692] (1 superfamily)
  28. 2245680k.30: Synthetic high affinity IgE receptor antagonists [64703] (1 superfamily)
  29. 2245693k.31: Glytm1bzip [70053] (1 superfamily)
  30. 2245700k.32: Trp-cage miniprotein [75769] (1 superfamily)
  31. k.33: IFN mimetic syr6 [75779] (1 superfamily)
  32. 2245714k.34: TAZ (CH) Zn-binding domain based design [75784] (1 superfamily)
  33. 2245720k.35: Beta-sheet designs [75789] (1 superfamily)
  34. k.36: PW2, a tryptophan-rich anticocidial peptide [75796] (1 superfamily)
  35. 2245739k.37: Artificial ankyrin repeat proteins [83017] (1 superfamily)
  36. 2245761k.38: TPR domain-based design [90307] (1 superfamily)
  37. k.39: Metalloporphyrin-binding designed peptides [90314] (1 superfamily)
  38. 2245789k.40: Designed trimeric coiled-coil [100903] (1 superfamily)
  39. 2245815k.41: New fold designs [103774] (1 superfamily)
  40. 2245823k.42: In vitro evolution products [103779] (1 superfamily)
  41. 2245829k.43: Carboxypeptidase A prodomain-based design [103789] (1 superfamily)
  42. k.44: Designed EF-hand type cation-binding loop [111554] (1 superfamily)
  43. 2245843k.45: Ubiquitin [144344] (1 superfamily)
  44. 2245862k.46: Cro lambda fold design [144349] (1 superfamily)

More info for Class k: Designed proteins

Timeline for Class k: Designed proteins: