SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Class k: Designed proteins

  1. Root: SCOP 1.55
  2. Class k: Designed proteins [58788] (24 folds)

Folds:

  1. k.1: Hybrid and chimeric proteins [58789] (1 superfamily)
  2. k.2: Amphiphilic (amphipathic) alpha helix [58798] (1 superfamily)
  3. k.3: Collagen-like peptides [58805] (1 superfamily)
  4. k.4: Alpha helical bundle [58812] (1 superfamily)
  5. k.5: Alpha helical bundle [58817] (1 superfamily)
  6. k.6: Designed heterodimeric leucine zipper [58822] (1 superfamily)
  7. k.7: Thermostable heterotrimeric coiled coil [58827] (1 superfamily)
  8. k.8: Designed four helix bundle protein [58832] (1 superfamily)
  9. k.9: Designed single chain three-helix bundle [58839] (1 superfamily)
  10. k.10: Peptide f (amphiphilic octadecapeptide) [58846] (1 superfamily)
  11. k.11: Retro-GCN4 leucine zipper [58851] (1 superfamily)
  12. k.12: Zinc finger design [58856] (1 superfamily)
  13. k.13: Protein A Ig(Fc)-binding domain mimics [58863] (1 superfamily)
  14. k.14: Zinc finger based beta-beta-alpha motif [58868] (1 superfamily)
  15. k.15: Alpha-t-alpha, a de novo designed peptide [58877] (1 superfamily)
  16. k.16: alpha2d [58882] (1 superfamily)
  17. k.17: RH4 designed right-handed coiled coil tetramer [58887] (1 superfamily)
  18. k.18: Erythropoietin (EPO) mimetic peptide 1 [58892] (1 superfamily)
  19. k.19: IL-1 receptor type 1 antagonist peptide AF10847 [58897] (1 superfamily)
  20. k.20: Octreotide (Sandostatine), a somatostatine analogue [58902] (1 superfamily)
  21. k.21: Calmodulin [58907] (1 superfamily)
  22. k.22: Prototype WW domain [58912] (1 superfamily)
  23. k.23: Scorpion toxin-based designs [58917] (1 superfamily)
  24. k.24: Inhibitor of mammalian ribonucleotide reductase [58925] (1 superfamily)

More info for Class k: Designed proteins

Timeline for Class k: Designed proteins: