SCOPe 2.08: Family g.17.1.2: Transforming growth factor (TGF)-beta

Lineage for Family g.17.1.2: Transforming growth factor (TGF)-beta

1. Root: SCOPe 2.08

2. Class g: Small proteins [56992] (100 folds)

3. Fold g.17: Cystine-knot cytokines [57500] (1 superfamily)
   disulfide-rich fold; common core is all-beta

4. Superfamily g.17.1: Cystine-knot cytokines [57501] (8 families)

5. Family g.17.1.2: Transforming growth factor (TGF)-beta [57507] (8 proteins)

Proteins:

1. Activin A (Inhibin beta A) [90170] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [90171] (10 PDB entries)
     Uniprot P08476 311-426

2. Bone morphogenetic protein-2 (BMP-2) [57516] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57517] (16 PDB entries)

3. Bone morphogenetic protein-7 (BMP-7) [57514] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57515] (4 PDB entries)

4. Glial cell-derived neurotrophic factor, GDNF [57518] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [57519] (1 PDB entry)

5. TGF-beta1 [57512] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57513] (6 PDB entries)

6. TGF-beta2 [57510] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [57511] (6 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [330451] (2 PDB entries)

7. TGF-beta3 [57508] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57509] (5 PDB entries)

8. automated matches [190307] (2 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [187121] (9 PDB entries)

   2. Species Zebrafish (Danio rerio) [TaxId:7955] [398216] (1 PDB entry)

More info for Family g.17.1.2: Transforming growth factor (TGF)-beta

Timeline for Family g.17.1.2: Transforming growth factor (TGF)-beta:

• Family g.17.1.2: Transforming growth factor (TGF)-beta first appeared (with stable ids) in SCOP 1.55
  
• Family g.17.1.2: Transforming growth factor (TGF)-beta appears in SCOPe 2.07