SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold f.4: Transmembrane beta-barrels

  1. Root: SCOPe 2.06
  2. 2223823Class f: Membrane and cell surface proteins and peptides [56835] (59 folds)
  3. 2224301Fold f.4: Transmembrane beta-barrels [56924] (7 superfamilies)
    not a true fold, gathers together transmembrane barrels of different (n,S)


  1. 2224302f.4.1: OMPA-like [56925] (5 families) (S)
    forms (8,10) barrel
  2. 2224393f.4.2: Outer membrane phospholipase A (OMPLA) [56931] (1 family) (S)
    forms (12,16) barrel
  3. 2224406f.4.3: Porins [56935] (5 families) (S)
  4. 2224627f.4.4: OMPT-like [69917] (3 families) (S)
    forms (10,12) barrel
  5. 2224647f.4.5: Autotransporter [103515] (1 family) (S)
    forms (12,14) barrel; contains a long alpha-helix running along the barrel axis
    automatically mapped to Pfam PF03797
  6. 2224653f.4.6: Tsx-like channel [111364] (1 family) (S)
    forms (12,16) barrel
    automatically mapped to Pfam PF03502
  7. 2224663f.4.7: Outer membrane carboxylate (Occ) channels [310584] (3 families) (S)
    Pfam PF03573; Phylogeny discussed in PubMed 22272184
    labile trimers according to PubMed 17952093; each subunit forms (18,22) barrel

More info for Fold f.4: Transmembrane beta-barrels

Timeline for Fold f.4: Transmembrane beta-barrels: