Lineage for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

  1. Root: SCOPe 2.08
  2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)
  3. Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
    contains a cluster of helices and an alpha+beta sandwich
  4. Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (4 families) (S)
  5. Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (19 proteins)
    in the multi-domain class (e), this applies to domains with different numbers of (sub)domains than the most common domain

Proteins:

  1. 6-aminohexanoate-dimer hydrolase NylC [160972] (1 species)
    NylB'
  2. AMPC beta-Lactamase, class C [56618] (4 species)
    contains small alpha+beta subdomain inserted in the common fold
    1. Species Chromohalobacter sp. [TaxId:169132] [270012] (7 PDB entries)
    2. Species Citrobacter freundii [TaxId:546] [56619] (3 PDB entries)
    3. Species Enterobacter cloacae, P99, cephalosporinase [TaxId:550] [56620] (10 PDB entries)
      Uniprot P05364 22-380 ! Uniprot P05364 22-381
    4. Species Escherichia coli, cephalosporinase [TaxId:562] [56621] (115 PDB entries)
  3. beta-Lactamase, class A [56606] (16 species)
    1. Species Bacillus licheniformis [TaxId:1402] [56612] (14 PDB entries)
    2. Species Enterobacter cloacae, NMC-A carbapenemase [TaxId:550] [56613] (2 PDB entries)
    3. Species Escherichia coli, TEM-1 [TaxId:562] [56607] (63 PDB entries)
    4. Species Escherichia coli, TOHO-1 [TaxId:562] [56608] (27 PDB entries)
    5. Species Klebsiella pneumoniae [TaxId:573] [225597] (9 PDB entries)
    6. Species Klebsiella pneumoniae, SHV-1 [TaxId:573] [56609] (27 PDB entries)
      inhibited by tazobactam
      Uniprot Q5PSW7 ! Uniprot P14557 22-286
    7. Species Klebsiella pneumoniae, SHV-2 [TaxId:573] [90082] (10 PDB entries)
      almost identical sequence to SHV-1
    8. Species Klebsiella pneumoniae, TEM52 [TaxId:573] [64473] (1 PDB entry)
    9. Species Mycobacterium fortuitum [TaxId:1766] [56615] (2 PDB entries)
    10. Species Proteus vulgaris [TaxId:585] [75596] (1 PDB entry)
    11. Species Pseudomonas aeruginosa, PER-1 [TaxId:287] [56616] (1 PDB entry)
    12. Species Pseudomonas aeruginosa, PSE-4 carbenicillinase [TaxId:287] [56610] (2 PDB entries)
    13. Species Serratia marcescens, Sme-1 [TaxId:615] [56617] (1 PDB entry)
      imipenem-hydrolyzing
    14. Species Staphylococcus aureus [TaxId:1280] [56611] (16 PDB entries)
    15. Species Stenotrophomonas maltophilia, L2 [TaxId:40324] [103374] (2 PDB entries)
    16. Species Streptomyces albus G [TaxId:1962] [56614] (1 PDB entry)
  4. Class D beta-lactamase [56622] (4 species)
    1. Species Escherichia coli, OXA-1 [TaxId:562] [82837] (4 PDB entries)
    2. Species Pseudomonas aeruginosa, OXA-10 [TaxId:287] [56623] (33 PDB entries)
    3. Species Pseudomonas aeruginosa, OXA-13 [TaxId:287] [64474] (4 PDB entries)
    4. Species Salmonella typhimurium, OXA-2 [TaxId:90371] [90083] (1 PDB entry)
  5. D,D-carboxypeptidase DacA, N-terminal domain [118181] (1 species)
  6. D-ala carboxypeptidase/transpeptidase [56603] (2 species)
    1. Species Streptomyces sp., K15 [TaxId:1931] [56604] (8 PDB entries)
    2. Species Streptomyces sp., R61 [TaxId:1931] [56605] (14 PDB entries)
      Uniprot P15555 34-378 ! Uniprot P15555
  7. D-Amino acid amidase DaaA [144038] (1 species)
  8. D-aminopeptidase, N-terminal domain [56626] (1 species)
  9. Esterase EstB [69873] (1 species)
  10. Pencillin binding protein 4 (PbpD), N-terminal domain [111287] (1 species)
  11. Penicillin binding protein 2a (PBP2A), C-terminal domain [82838] (1 species)
  12. Penicillin receptor BlaR, C-terminal domain [103375] (1 species)
    closely related to class D beta-lactamase
  13. Penicillin-binding protein 1a, transpeptidase domain [144034] (1 species)
  14. Penicillin-binding protein 1b, transpeptidase domain [144036] (1 species)
  15. Penicillin-binding protein 2, PBP2 [160970] (1 species)
  16. Penicillin-binding protein 2x (pbp-2x), transpeptidase domain [56624] (1 species)
  17. Penicillin-binding protein 5, N-terminal domain [69875] (1 species)
  18. Regulatory protein BlaR1 [111289] (1 species)
  19. automated matches [190161] (29 species)
    not a true protein
    1. Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [196311] (1 PDB entry)
    2. Species Bacillus licheniformis [TaxId:1402] [188244] (18 PDB entries)
    3. Species Citrobacter freundii [TaxId:546] [235913] (4 PDB entries)
    4. Species Citrobacter sedlakii [TaxId:67826] [188289] (5 PDB entries)
    5. Species Enterobacter cloacae [TaxId:550] [187307] (6 PDB entries)
    6. Species Escherichia coli [TaxId:469008] [188520] (1 PDB entry)
    7. Species Escherichia coli [TaxId:562] [187306] (109 PDB entries)
    8. Species Escherichia coli [TaxId:668369] [189787] (1 PDB entry)
    9. Species Escherichia coli [TaxId:83333] [321358] (1 PDB entry)
    10. Species Escherichia sp. [TaxId:299586] [188841] (1 PDB entry)
    11. Species Klebsiella oxytoca [TaxId:571] [188743] (1 PDB entry)
    12. Species Klebsiella pneumoniae [TaxId:1125630] [268559] (6 PDB entries)
    13. Species Klebsiella pneumoniae [TaxId:1276653] [388782] (1 PDB entry)
    14. Species Klebsiella pneumoniae [TaxId:1432554] [407388] (2 PDB entries)
    15. Species Klebsiella pneumoniae [TaxId:484021] [361809] (1 PDB entry)
    16. Species Klebsiella pneumoniae [TaxId:573] [188184] (14 PDB entries)
    17. Species Klebsiella pneumoniae [TaxId:72407] [271107] (1 PDB entry)
    18. Species Morganella morganii [TaxId:582] [226088] (1 PDB entry)
    19. Species Oceanobacillus iheyensis [TaxId:182710] [189232] (1 PDB entry)
    20. Species Pneumococcus (Streptococcus pneumoniae) [TaxId:1313] [188417] (5 PDB entries)
    21. Species Pseudomonas aeruginosa [TaxId:287] [225853] (6 PDB entries)
    22. Species Serratia fonticola [TaxId:47917] [195324] (4 PDB entries)
    23. Species Staphylococcus aureus [TaxId:1280] [189852] (11 PDB entries)
    24. Species Staphylococcus aureus [TaxId:158878] [256157] (6 PDB entries)
    25. Species Staphylococcus aureus [TaxId:93062] [352201] (11 PDB entries)
    26. Species Streptococcus pneumoniae [TaxId:171101] [352954] (2 PDB entries)
    27. Species Streptomyces sp. [TaxId:31952] [186885] (1 PDB entry)
    28. Species Vibrio cholerae [TaxId:666] [364228] (2 PDB entries)
    29. Species Yersinia enterocolitica [TaxId:393305] [278691] (1 PDB entry)

More info for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

Timeline for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase: