Lineage for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2556795Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
    unusual fold, defines family
  4. 2556796Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families) (S)
  5. 2556797Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 protein domains)
    N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
    automatically mapped to Pfam PF02866

Protein Domains:

  1. 2556798L-2-hydroxyisocapronate dehydrogenase, L-HICDH [56337] (1 species)
  2. 2556804Lactate dehydrogenase [56339] (20 species)
    1. 2556805Species Archaeoglobus fulgidus [TaxId:2234] [111253] (4 PDB entries)
      Uniprot O08349
    2. 2556810Species Bacillus stearothermophilus [TaxId:1422] [56344] (3 PDB entries)
    3. 2556827Species Bifidobacterium longum, strain am101-2 [TaxId:216816] [56346] (2 PDB entries)
    4. 2556832Species Chicken (Gallus gallus) [TaxId:9031] [318261] (1 PDB entry)
    5. 2556837Species Clostridium thermocellum [TaxId:1515] [118160] (1 PDB entry)
      Uniprot Q4CDK5
    6. 2556839Species Cryptosporidium parvum [TaxId:5807] [225186] (10 PDB entries)
    7. 2556864Species Dogfish (Squalus acanthias) [TaxId:7797] [56342] (3 PDB entries)
    8. 2556868Species Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [64444] (2 PDB entries)
    9. 2556875Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (21 PDB entries)
    10. 2556952Species Lactobacillus casei [TaxId:1582] [56345] (6 PDB entries)
    11. 2556982Species Lactobacillus pentosus [TaxId:1589] [69843] (1 PDB entry)
    12. 2556987Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [56343] (14 PDB entries)
    13. 2557008Species Mouse (Mus musculus) [TaxId:10090] [56341] (1 PDB entry)
    14. 2557013Species Pig (Sus scrofa) [TaxId:9823] [56340] (3 PDB entries)
    15. 2557020Species Plasmodium berghei [TaxId:5821] [103325] (1 PDB entry)
    16. 2557023Species Plasmodium vivax [TaxId:5855] [225044] (3 PDB entries)
    17. 2557033Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [346390] (2 PDB entries)
    18. 2557042Species Thermotoga maritima [TaxId:2336] [56347] (1 PDB entry)
    19. 2557044Species Thermus caldophilus [TaxId:272] [226615] (2 PDB entries)
    20. 2557053Species Toxoplasma gondii [TaxId:5811] [103326] (5 PDB entries)
  3. 2557069Malate dehydrogenase [56329] (12 species)
    1. 2557070Species Aquaspirillum arcticum [TaxId:87645] [56336] (3 PDB entries)
    2. 2557074Species Chlorobium tepidum [TaxId:1097] [69841] (1 PDB entry)
    3. 2557077Species Chlorobium vibrioforme [TaxId:1098] [69842] (2 PDB entries)
    4. 2557086Species Chloroflexus aurantiacus [TaxId:1108] [69840] (7 PDB entries)
      Uniprot P80040
    5. 2557101Species Chloroflexus sp. [TaxId:480224] [236535] (1 PDB entry)
    6. 2557104Species Escherichia coli [TaxId:562] [56333] (4 PDB entries)
    7. 2557115Species Flaveria bidentis, chloroplast [TaxId:4224] [56332] (1 PDB entry)
    8. 2557117Species Haloarcula marismortui [TaxId:2238] [56335] (6 PDB entries)
    9. 2557132Species Pig (Sus scrofa) [TaxId:9823] [56330] (3 PDB entries)
    10. 2557141Species Sorghum (Sorghum vulgare), chloroplast [TaxId:4558] [56331] (1 PDB entry)
    11. 2557146Species Thermus flavus [TaxId:274] [56334] (2 PDB entries)
    12. 2557151Species Thermus thermophilus [TaxId:274] [82806] (7 PDB entries)
      identical sequence to that from the Thermus flavus enzyme
  4. 2557166MJ0490, lactate/malate dehydrogenase [64446] (1 species)
  5. 2557171automated matches [226882] (7 species)
    not a true protein
    1. 2557172Species Escherichia coli K-12 [TaxId:83333] [225274] (2 PDB entries)
    2. 2557181Species Haloarcula marismortui [TaxId:2238] [225148] (4 PDB entries)
    3. 2557198Species Human (Homo sapiens) [TaxId:9606] [225057] (8 PDB entries)
    4. 2557231Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [254909] (5 PDB entries)
    5. 2557237Species Norway rat (Rattus norvegicus) [TaxId:10116] [226330] (13 PDB entries)
    6. 2557294Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [225719] (6 PDB entries)
    7. 2557339Species Toxoplasma gondii [TaxId:5811] [233101] (1 PDB entry)

More info for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Timeline for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain: