Lineage for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2206813Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
    unusual fold, defines family
  4. 2206814Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families) (S)
  5. 2206815Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 protein domains)
    N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
    automatically mapped to Pfam PF02866

Protein Domains:

  1. 2206816L-2-hydroxyisocapronate dehydrogenase, L-HICDH [56337] (1 species)
  2. 2206822Lactate dehydrogenase [56339] (19 species)
    1. 2206823Species Archaeoglobus fulgidus [TaxId:2234] [111253] (4 PDB entries)
      Uniprot O08349
    2. 2206828Species Bacillus stearothermophilus [TaxId:1422] [56344] (3 PDB entries)
    3. 2206845Species Bifidobacterium longum, strain am101-2 [TaxId:216816] [56346] (2 PDB entries)
    4. 2206850Species Clostridium thermocellum [TaxId:1515] [118160] (1 PDB entry)
      Uniprot Q4CDK5
    5. 2206852Species Cryptosporidium parvum [TaxId:5807] [225186] (10 PDB entries)
    6. 2206877Species Dogfish (Squalus acanthias) [TaxId:7797] [56342] (3 PDB entries)
    7. 2206881Species Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [64444] (2 PDB entries)
    8. 2206888Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (16 PDB entries)
    9. 2206953Species Lactobacillus casei [TaxId:1582] [56345] (6 PDB entries)
    10. 2206983Species Lactobacillus pentosus [TaxId:1589] [69843] (1 PDB entry)
    11. 2206988Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [56343] (14 PDB entries)
    12. 2207009Species Mouse (Mus musculus) [TaxId:10090] [56341] (1 PDB entry)
    13. 2207014Species Pig (Sus scrofa) [TaxId:9823] [56340] (3 PDB entries)
    14. 2207021Species Plasmodium berghei [TaxId:5821] [103325] (1 PDB entry)
    15. 2207024Species Plasmodium vivax [TaxId:5855] [225044] (3 PDB entries)
    16. 2207033Species Thermotoga maritima [TaxId:2336] [56347] (1 PDB entry)
    17. 2207035Species Thermus caldophilus [TaxId:272] [226615] (2 PDB entries)
    18. 2207044Species Toxoplasma gondii [TaxId:5811] [103326] (5 PDB entries)
    19. 2274960Species Gallus gallus [TaxId:9031] [318261] (1 PDB entry)
  3. 2207060Malate dehydrogenase [56329] (12 species)
    1. 2207061Species Aquaspirillum arcticum [TaxId:87645] [56336] (3 PDB entries)
    2. 2207065Species Chlorobium tepidum [TaxId:1097] [69841] (1 PDB entry)
    3. 2207068Species Chlorobium vibrioforme [TaxId:1098] [69842] (2 PDB entries)
    4. 2207077Species Chloroflexus aurantiacus [TaxId:1108] [69840] (7 PDB entries)
      Uniprot P80040
    5. 2207092Species Chloroflexus sp. [TaxId:480224] [236535] (1 PDB entry)
    6. 2207095Species Escherichia coli [TaxId:562] [56333] (4 PDB entries)
    7. 2207106Species Flaveria bidentis, chloroplast [TaxId:4224] [56332] (1 PDB entry)
    8. 2207108Species Haloarcula marismortui [TaxId:2238] [56335] (6 PDB entries)
    9. 2207123Species Pig (Sus scrofa) [TaxId:9823] [56330] (3 PDB entries)
    10. 2207132Species Sorghum (Sorghum vulgare), chloroplast [TaxId:4558] [56331] (1 PDB entry)
    11. 2207137Species Thermus flavus [TaxId:274] [56334] (2 PDB entries)
    12. 2207142Species Thermus thermophilus [TaxId:274] [82806] (7 PDB entries)
      identical sequence to that from the Thermus flavus enzyme
  4. 2207157MJ0490, lactate/malate dehydrogenase [64446] (1 species)
  5. 2207162automated matches [226882] (7 species)
    not a true protein
    1. 2207163Species Escherichia coli K-12 [TaxId:83333] [225274] (2 PDB entries)
    2. 2207172Species Haloarcula marismortui [TaxId:2238] [225148] (4 PDB entries)
    3. 2207189Species Human (Homo sapiens) [TaxId:9606] [225057] (8 PDB entries)
    4. 2207222Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [254909] (5 PDB entries)
    5. 2207228Species Norway rat (Rattus norvegicus) [TaxId:10116] [226330] (13 PDB entries)
    6. 2207285Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [225719] (8 PDB entries)
    7. 2207326Species Toxoplasma gondii [TaxId:5811] [233101] (1 PDB entry)

More info for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Timeline for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain: