SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold d.153: Ntn hydrolase-like

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2201124Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

Superfamilies:

  1. 2201125d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  2. 2205547d.153.2: Archaeal IMP cyclohydrolase PurO [75569] (1 family) (S)
    has a putative active site in the same topological location as the Ntn hydrolase but lacks the N-terminal nucleophile
    automatically mapped to Pfam PF07826

More info for Fold d.153: Ntn hydrolase-like

Timeline for Fold d.153: Ntn hydrolase-like: