Lineage for Superfamily d.153.2: Archaeal IMP cyclohydrolase PurO

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies) 4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.2: Archaeal IMP cyclohydrolase PurO [75569] (1 family) has a putative active site in the same topological location as the Ntn hydrolase but lacks the N-terminal nucleophile automatically mapped to Pfam PF07826