SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold d.110: Profilin-like

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2188697Fold d.110: Profilin-like [55769] (10 superfamilies)
    core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha


  1. 2188698d.110.1: Profilin (actin-binding protein) [55770] (2 families) (S)
  2. 2188766d.110.2: GAF domain-like [55781] (5 families) (S)
    alpha(2)-beta(3)-alpha-beta(3)-alpha; antiparallel beta-sheet: order 321654
  3. 2188938d.110.3: PYP-like sensor domain (PAS domain) [55785] (8 families) (S)
  4. 2189269d.110.4: SNARE-like [64356] (5 families) (S)
  5. 2189315d.110.5: Pheromone-binding domain of LuxR-like quorum-sensing transcription factors [75516] (1 family) (S)
    alpha(2)-beta(2)-alpha(2)-beta(3)-alpha; possibly related to the PAS domain
    automatically mapped to Pfam PF03472
  6. 2189327d.110.6: Sensory domain-like [103190] (3 families) (S)
    alpha(2)-beta(2)-alpha(2)-beta(3); possibly related to the PAS domain
  7. 2189384d.110.7: Roadblock/LC7 domain [103196] (1 family) (S)
    alpha-beta(2)-alpha-beta(3)-alpha; structurally most similar to the SNARE-like superfamily with a circular permutation of the terminal helices
  8. 2189434d.110.8: YeeU-like [143737] (1 family) (S)
    beta(2)-alpha-beta(3); 2 layers, a/b; there is an oligomerization interface instead of the 'missing' helical layer
    automatically mapped to Pfam PF06154
  9. 2189447d.110.9: GlcG-like [143744] (1 family) (S)
    alpha-beta(2)-alpha(3)-beta(2)-alpha; similar to the Roadblock/LC7 domain
    automatically mapped to Pfam PF03928
  10. 2189455d.110.10: YNR034W-A-like [160683] (1 family) (S)
    automatically mapped to Pfam PF11503

More info for Fold d.110: Profilin-like

Timeline for Fold d.110: Profilin-like: