SCOP 1.75: Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD)

Lineage for Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.50: dsRBD-like [54767] (5 superfamilies)
   alpha-beta(3)-alpha; 2 layers: alpha/beta

4. Superfamily d.50.1: dsRNA-binding domain-like [54768] (3 families)

5. Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD) [54769] (12 proteins)
   Pfam PF00035

Proteins:

1. ATP-dependent RNA helicase A, Dhx9 [117901] (1 species)
   formerly hypothetical protein bab28848

   • Species Mouse (Mus musculus) [TaxId:10090] [117902] (2 PDB entries)
     Uniprot O70133 4-89, 168-262

2. Dgcr8 protein [143206] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [143207] (1 PDB entry)
     Uniprot Q8WYQ5 502-586

3. Double-stranded RNA-binding protein A, second dsRBD [54770] (1 species)

   • Species Xenopus laevis [TaxId:8355] [54771] (1 PDB entry)

4. dsRNA-dependent protein kinase pkr [54774] (2 species)
   contains tandem repeat of two dsRBD

   1. Species Human (Homo sapiens) [TaxId:9606] [54775] (1 PDB entry)

   2. Species Mouse (Mus musculus) [TaxId:10090] [143201] (2 PDB entries)
      Uniprot Q03963 1-85! Uniprot Q03963 96-181

5. dsRNA-specific editase 1 [143202] (1 species)
   duplication: contains two dsRBD domains

   • Species Rat (Rattus norvegicus) [TaxId:10116] [143203] (2 PDB entries)
     Uniprot P51400 231-301! Uniprot P51400 74-146

6. Interferon-inducible double stranded RNA-dependent protein kinase activator A [143204] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [143205] (1 PDB entry)
     Uniprot O75569 32-104

7. RNase III, C-terminal domain [54776] (3 species)

   1. Species Aquifex aeolicus [TaxId:63363] [102927] (9 PDB entries)

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110913] (3 PDB entries)
      Uniprot Q02555 364-447
      Uniprot Q02555 366-453
      Uniprot Q02555 363-443
      Uniprot Q02555 364-447 ! Uniprot Q02555 366-453 ! Uniprot Q02555 363-443

   3. Species Thermotoga maritima [TaxId:2336] [82644] (1 PDB entry)

8. Spermatid perinuclear RNA-binding protein [143210] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [143211] (1 PDB entry)
     Uniprot Q96SI9 378-461

9. staufen homolog 2 [110914] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [110915] (1 PDB entry)
     Uniprot Q9D5N7 3-78

10. Staufen, domain III [54772] (1 species)

    • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [54773] (2 PDB entries)

11. TAR RNA-binding protein 2 [143208] (1 species)
    duplication: contains three dsRBD

    • Species Human (Homo sapiens) [TaxId:9606] [143209] (1 PDB entry)
      Uniprot Q15633 150-225

12. tRNA-dihydrouridine synthase 2-like, Dus2l (2310016k04Rik) [117903] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117904] (1 PDB entry)
      Uniprot Q9D7B1 350-464

More info for Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD)

Timeline for Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD):

• Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD) first appeared (with stable ids) in SCOP 1.55
  
• Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD) appears in SCOP 1.73
  
• Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD) appears in SCOPe 2.01
  
• Family d.50.1.1: Double-stranded RNA-binding domain (dsRBD) appears in the current release, SCOPe 2.08