SCOPe 2.02: Family c.61.1.1: Phosphoribosyltransferases (PRTases)

Lineage for Family c.61.1.1: Phosphoribosyltransferases (PRTases)

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.61: PRTase-like [53270] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest

4. Superfamily c.61.1: PRTase-like [53271] (3 families)

5. Family c.61.1.1: Phosphoribosyltransferases (PRTases) [53272] (16 proteins)

Proteins:

1. Adenine PRTase [53288] (5 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [69541] (2 PDB entries)

   2. Species Giardia intestinalis [TaxId:5741] [82455] (2 PDB entries)

   3. Species Human (Homo sapiens) [TaxId:9606] [102536] (4 PDB entries)

   4. Species Leishmania donovani [TaxId:5661] [53289] (4 PDB entries)

   5. Species Leishmania tarentolae [TaxId:5689] [102535] (1 PDB entry)

2. Glutamine PRPP amidotransferase, C-terminal domain [53278] (2 species)

   1. Species Bacillus subtilis [TaxId:1423] [53279] (2 PDB entries)

   2. Species Escherichia coli [TaxId:562] [53280] (5 PDB entries)

3. Guanine PRTase [53281] (1 species)

   • Species Giardia intestinalis [TaxId:5741] [53282] (2 PDB entries)

4. Hypoxanthine PRTase [53286] (3 species)

   1. Species Escherichia coli [TaxId:562] [75255] (3 PDB entries)

   2. Species Salmonella typhimurium [TaxId:90371] [89728] (1 PDB entry)

   3. Species Trypanosoma cruzi [TaxId:5693] [53287] (9 PDB entries)
      Uniprot Q27796

5. Hypoxanthine-guanine PRTase (HGPRTase) [53283] (3 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [53284] (8 PDB entries)

   2. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [53285] (1 PDB entry)

   3. Species Thermoanaerobacter tengcongensis [TaxId:119072] [117671] (1 PDB entry)
      Uniprot Q8R7L0

6. Hypoxanthine-guanine-xanthine PRTase [53275] (3 species)

   1. Species Leishmania tarentolae [TaxId:5689] [110658] (1 PDB entry)
      Uniprot Q9NJI5

   2. Species Toxoplasma gondii [TaxId:5811] [53277] (5 PDB entries)

   3. Species Tritrichomonas foetus [TaxId:5724] [53276] (1 PDB entry)

7. Orotate PRTase [53290] (3 species)

   1. Species Escherichia coli [TaxId:562] [53292] (1 PDB entry)

   2. Species Salmonella typhimurium [TaxId:90371] [53291] (3 PDB entries)

   3. Species Streptococcus pyogenes [TaxId:1314] [142553] (1 PDB entry)
      Uniprot Q9A076 1-208

8. Pprobable purine phosphoribosyltransferase PH0095 [142560] (1 species)

   • Species Pyrococcus horikoshii [TaxId:53953] [142561] (1 PDB entry)
     Uniprot O57827 1-153

9. Pur operon repressor (PurR), C-terminal domain [102539] (1 species)

   • Species Bacillus subtilis [TaxId:1423] [102540] (2 PDB entries)

10. Putative phosphoribosyltransferase TT1426 (TTHA1462) [117673] (1 species)

    • Species Thermus thermophilus [TaxId:274] [117674] (1 PDB entry)
      Uniprot Q5SIB2

11. Putative phosphoribosyltransferase TTHA1613 [142558] (1 species)
    putative APRTase in UniProt

    • Species Thermus thermophilus [TaxId:274] [142559] (1 PDB entry)
      Uniprot Q5SHW7 2-175

12. Pyrimidine operon regulator PyrR [109612] (4 species)
    bifunctional protein; contains the uracil PRTase and Pyr RNA-binding activities

    1. Species Bacillus caldolyticus [TaxId:1394] [110659] (4 PDB entries)
       Uniprot P41007

    2. Species Bacillus subtilis [TaxId:1423] [53294] (2 PDB entries)

    3. Species Mycobacterium tuberculosis [TaxId:1773] [117672] (1 PDB entry)
       Uniprot P71807

    4. Species Thermus thermophilus [TaxId:274] [102537] (1 PDB entry)
       TT1027

13. Uracil PRTase, Upp [53293] (5 species)

    1. Species Bacillus caldolyticus [TaxId:1394] [75256] (1 PDB entry)

    2. Species Sulfolobus solfataricus [TaxId:2287] [142555] (5 PDB entries)
       Uniprot Q980Q4 2-216

    3. Species Thermotoga maritima [TaxId:2336] [102538] (1 PDB entry)
       TM0721

    4. Species Thermus thermophilus [TaxId:274] [142554] (1 PDB entry)
       Uniprot Q72J35 1-208

    5. Species Toxoplasma gondii [TaxId:5811] [53295] (6 PDB entries)

14. Xanthine phosphoribosyltransferase [142556] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [142557] (2 PDB entries)
      Uniprot P42085 1-191

15. Xanthine-guanine PRTase (XPRTase) [53273] (2 species)

    1. Species Escherichia coli [TaxId:562] [53274] (5 PDB entries)

    2. Species Thermoanaerobacter tengcongensis [TaxId:119072] [142552] (1 PDB entry)
       Uniprot Q8R7L0 3-180

16. automated matches [190074] (7 species)
    not a true protein

    1. Species Burkholderia pseudomallei [TaxId:28450] [188498] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [187905] (1 PDB entry)

    3. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [188472] (1 PDB entry)

    4. Species Thermoanaerobacter tengcongensis [TaxId:119072] [187747] (1 PDB entry)

    5. Species Thermus thermophilus [TaxId:274] [188051] (1 PDB entry)

    6. Species Thermus thermophilus [TaxId:300852] [186795] (1 PDB entry)

    7. Species Vibrio cholerae [TaxId:666] [189453] (1 PDB entry)

More info for Family c.61.1.1: Phosphoribosyltransferases (PRTases)

Timeline for Family c.61.1.1: Phosphoribosyltransferases (PRTases):

• Family c.61.1.1: Phosphoribosyltransferases (PRTases) first appeared (with stable ids) in SCOP 1.55
  
• Family c.61.1.1: Phosphoribosyltransferases (PRTases) appears in SCOPe 2.01
  
• Family c.61.1.1: Phosphoribosyltransferases (PRTases) appears in SCOPe 2.03
  
• Family c.61.1.1: Phosphoribosyltransferases (PRTases) appears in the current release, SCOPe 2.08