SCOP 1.71: Family c.1.7.1: Aldo-keto reductases (NADP)

Lineage for Family c.1.7.1: Aldo-keto reductases (NADP)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (1 family)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (15 proteins)
   Common fold covers whole protein structure

Proteins:

1. 2,5-diketo-D-gluconic acid reductase A [51443] (3 species)

   1. Species Corynebacterium sp. [TaxId:1720] [51444] (3 PDB entries)

   2. Species Escherichia coli [TaxId:562] [102053] (1 PDB entry)

   3. Species Thermotoga maritima [TaxId:243274] [117365] (1 PDB entry)

2. 20alpha-hydroxysteroid dehydrogenase [109609] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [109610] (1 PDB entry)

   2. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [110348] (2 PDB entries)

3. 3-alpha-hydroxysteroid dehydrogenase [51439] (2 species)

   1. Species Human (Homo sapiens), type III [TaxId:9606] [69383] (2 PDB entries)
      bile acid binding protein

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [51440] (3 PDB entries)

4. Aflatoxin aldehyde reductase (akr7a1) [75056] (1 species)

   • Species Rat (Rattus norvegicus) [TaxId:10116] [75057] (1 PDB entry)

5. Aldose reductase (aldehyde reductase) [51436] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [51437] (21 PDB entries)

   2. Species Pig (Sus scrofa) [TaxId:9823] [51438] (8 PDB entries)

6. CHO reductase [51441] (1 species)

   • Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [51442] (1 PDB entry)

7. FR-1 (fibroblast growth factor-induced) protein [51432] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [51433] (1 PDB entry)

8. Hypothetical oxidoreductase YdhF [89459] (1 species)

   • Species Escherichia coli [TaxId:562] [89460] (2 PDB entries)

9. Hypothetical protein C07D8.6 [102049] (1 species)
   Aldo-keto reductase family 1 member c1

   • Species Nematode (Caenorhabditis elegans) [TaxId:6239] [102050] (1 PDB entry)

10. Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
    Aldo-keto reductase family 1 member c3

    • Species Human (Homo sapiens) [TaxId:9606] [102052] (7 PDB entries)

11. Putative oxidoreductase IolS [102054] (1 species)
    vegetative protein 147, VEG147, AKR11A

    • Species Bacillus subtilis [TaxId:1423] [102055] (2 PDB entries)

12. Putative oxidoreductase YhdN [102056] (1 species)
    General stress protein 69, GSP69, AKR11B

    • Species Bacillus subtilis [TaxId:1423] [102057] (1 PDB entry)

13. Tas protein [89461] (1 species)

    • Species Escherichia coli [TaxId:562] [89462] (1 PDB entry)

14. Voltage-dependent K+ channel beta subunit [51434] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [51435] (2 PDB entries)

15. Xylose reductase [75058] (1 species)

    • Species Fungi (Candida tenuis) [TaxId:45596] [75059] (5 PDB entries)

More info for Family c.1.7.1: Aldo-keto reductases (NADP)

Timeline for Family c.1.7.1: Aldo-keto reductases (NADP):

• Family c.1.7.1: Aldo-keto reductases (NADP) first appeared (with stable ids) in SCOP 1.55
  
• Family c.1.7.1: Aldo-keto reductases (NADP) appears in SCOP 1.69
  
• Family c.1.7.1: Aldo-keto reductases (NADP) appears in SCOP 1.73
  
• Family c.1.7.1: Aldo-keto reductases (NADP) appears in the current release, SCOPe 2.08