SCOP 1.71: Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain

Lineage for Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain

1. Root: SCOP 1.71

2. Class a: All alpha proteins [46456] (226 folds)

3. Fold a.38: HLH-like [47458] (2 superfamilies)
   4-helices; bundle, closed, left-handed twist; 2 crossover connections

4. Superfamily a.38.1: HLH, helix-loop-helix DNA-binding domain [47459] (1 family)
   dimer of two identical helix-loop-helix subunits

5. Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain [47460] (8 proteins)

Proteins:

1. Mad protein [81752] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [81753] (1 PDB entry)
     BHLHZ region; contains leucine-zipper motif

2. Max protein [47461] (2 species)
   BHLHZ region; contains leucine-zipper motif

   1. Species Human (Homo sapiens) [TaxId:9606] [47462] (4 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [47463] (1 PDB entry)

3. Myc proto-oncogene protein [81750] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [81751] (1 PDB entry)
     BHLHZ region; contains leucine-zipper motif

4. Myod B/HLH domain [47464] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [47465] (1 PDB entry)

5. Pho4 B/HLH domain [47468] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [47469] (1 PDB entry)

6. SREBP-1a [47470] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47471] (1 PDB entry)

7. SREBP-2 [101171] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [101172] (1 PDB entry)

8. Usf B/HLH domain [47466] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47467] (1 PDB entry)

More info for Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain

Timeline for Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain:

• Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain first appeared (with stable ids) in SCOP 1.55, called Family a.38.1.1: Helix-loop-helix DNA-binding domain
  
• Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain appears in SCOP 1.69
  
• Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain appears in SCOP 1.73
  
• Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain appears in the current release, SCOPe 2.08