SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1994264Fold a.38: HLH-like [47458] (2 superfamilies)
    4-helices; bundle, closed, left-handed twist; 2 crossover connections
  4. 1994265Superfamily a.38.1: HLH, helix-loop-helix DNA-binding domain [47459] (2 families) (S)
    dimer of two identical helix-loop-helix subunits
  5. 1994266Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain [47460] (8 protein domains)

Protein Domains:

  1. 1994267Mad protein [81752] (1 species)
  2. 1994271Max protein [47461] (2 species)
    BHLHZ region; contains leucine-zipper motif
    1. 1994272Species Human (Homo sapiens) [TaxId:9606] [47462] (4 PDB entries)
    2. 1994281Species Mouse (Mus musculus) [TaxId:10090] [47463] (1 PDB entry)
  3. 1994283Myc proto-oncogene protein [81750] (1 species)
  4. 1994287Myod B/HLH domain [47464] (1 species)
  5. 1994293Pho4 B/HLH domain [47468] (1 species)
  6. 1994297SREBP-1a [47470] (1 species)
  7. 1994303SREBP-2 [101171] (1 species)
  8. 1994309Usf B/HLH domain [47466] (1 species)

More info for Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain

Timeline for Family a.38.1.1: HLH, helix-loop-helix DNA-binding domain: