SCOPe 2.08: Domain d1hw4a_: 1hw4 A:

Lineage for d1hw4a_ (1hw4 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (47 PDB entries)

8. Domain d1hw4a_: 1hw4 A: [41054]
   complexed with edo, so4

Details for d1hw4a_

PDB Entry: 1hw4, 2.06 Å

PDB Description: structure of thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d1hw4a_:

Sequence, based on SEQRES records:

>d1hw4a_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

Sequence, based on observed residues (ATOM records):

>d1hw4a_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvgdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidt
iktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfni
asyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvek
iddfkaedfqiegynphptikme

Timeline for d1hw4a_:

• d1hw4a_ first appeared (with stable ids) in SCOP 1.55
  
• d1hw4a_ appears in SCOPe 2.07