PDB entry 1hw4

View 1hw4 on RCSB PDB site
Description: structure of thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
Class: transferase
Keywords: Thymidylate Synthase, Methyltransferase, TRANSFERASE
Deposited on 2001-01-09, released 2001-01-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: 0.224
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • modified residue (84)
      • modified residue (221)
      • conflict (240)
    Domains in SCOPe 2.08: d1hw4a_
  • Heterogens: SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hw4A (A:)
mghhhhhhdtdipttenltfqgacrlvancrdvrcrrllrnvmpvagselprrplppaaq
erdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkr
vfwkgvleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfq
wrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchal
cqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiy
lnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw4A (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvgdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidt
iktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfni
asyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvek
iddfkaedfqiegynphptikme