SCOPe 2.07: Domain d6wxnd_: 6wxn D:

Lineage for d6wxnd_ (6wxn D:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (129 PDB entries)
   Uniprot P00533 702-1018

8. Domain d6wxnd_: 6wxn D: [407261]
   automated match to d4zseb_
   complexed with anp, cl, mg, uej

Details for d6wxnd_

PDB Entry: 6wxn, 1.76 Å

PDB Description: egfr(t790m/v948r) in complex with ln3844

PDB Compounds: (D:) Epidermal growth factor receptor

SCOPe Domain Sequences for d6wxnd_:

Sequence, based on SEQRES records:

>d6wxnd_ d.144.1.7 (D:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwm
alesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppicti
dvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyral
mdeedmddvvdad

Sequence, based on observed residues (ATOM records):

>d6wxnd_ d.144.1.7 (D:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreakankeildeay
vmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiakg
mnyledrrlvhrdlaarnvlvktpqhvkitdfglakllvpikwmalesilhriythqsdv
wsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidads
rpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeevdad

Timeline for d6wxnd_:

• d6wxnd_ is new in SCOPe 2.07-stable
  
• d6wxnd_ appears in the current release, SCOPe 2.08