SCOPe 2.07: Domain d7axja1: 7axj A:142-434

Lineage for d7axja1 (7axj A:142-434)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Pregnane x receptor, PXR [63624] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63625] (31 PDB entries)

8. Domain d7axja1: 7axj A:142-434 [398451]
   Other proteins in same PDB: d7axja2
   automated match to d1m13a_
   complexed with cl6, est

Details for d7axja1

PDB Entry: 7axj, 2.3 Å

PDB Description: crystal structure of the hpxr-lbd in complex with estradiol and clotrimazole

PDB Compounds: (A:) Nuclear receptor subfamily 1 group I member 2

SCOPe Domain Sequences for d7axja1:

Sequence, based on SEQRES records:

>d7axja1 a.123.1.1 (A:142-434) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakwsq
vrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvi
syfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqllle
pmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnr
pqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgitgs

Sequence, based on observed residues (ATOM records):

>d7axja1 a.123.1.1 (A:142-434) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgvsreeaakwsqvrkdlcslkvslql
rgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisl
lkgaafelcqlrfntvfnaetgtwecgrlsyclegfqqlllepmlkfhymlkklqlheee
yvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkimamlte
lrsinaqhtqrllriqdihpfatplmqelfgitgs

Timeline for d7axja1:

• d7axja1 is new in SCOPe 2.07-stable
  
• d7axja1 appears in the current release, SCOPe 2.08