SCOPe 2.07: Domain d6v2xb_: 6v2x B:

Lineage for d6v2xb_ (6v2x B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (42 PDB entries)
   Uniprot Q02750 61-381

8. Domain d6v2xb_: 6v2x B: [395992]
   Other proteins in same PDB: d6v2xa_
   automated match to d5hzea_
   complexed with anp, mg, qo7

Details for d6v2xb_

PDB Entry: 6v2x, 3.09 Å

PDB Description: crystal structure of the braf:mek1 kinases in complex with amppnp and binimetinib

PDB Compounds: (B:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d6v2xb_:

Sequence, based on SEQRES records:

>d6v2xb_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
deqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihle
ikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagrip
eqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidamana
fvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcqvegd
aaetpprprtpgrplssygmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcl
iknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnqps

Sequence, based on observed residues (ATOM records):

>d6v2xb_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
deqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihle
ikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagrip
eqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidamana
fvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmpmaifell
dyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagw
lcstiglnqps

Timeline for d6v2xb_:

• d6v2xb_ is new in SCOPe 2.07-stable
  
• d6v2xb_ does not appear in SCOPe 2.08