SCOPe 2.07: Domain d7jusb_: 7jus B:

Lineage for d7jusb_ (7jus B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (35 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1319 PDB entries)

8. Domain d7jusb_: 7jus B: [390336]
   Other proteins in same PDB: d7jusc_
   automated match to d3cc6a_
   complexed with anp, mg, vkd

Details for d7jusb_

PDB Entry: 7jus, 2.99 Å

PDB Description: crystal structure of ksr2:mek1 in complex with amp-pnp, and allosteric mek inhibitor cobimetinib

PDB Compounds: (B:) kinase suppressor of ras 2

SCOPe Domain Sequences for d7jusb_:

Sequence, based on SEQRES records:

>d7jusb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tsiflqewdipfeqleigeligkgrfgqvyhgrwhgevairlidierdnedqlkafkrev
mayrqtrhenvvlfmgacmspphlaiitslckgrtlysvvrdakivldvnktrqiaqeiv
kgmgylhakgilhkdlksknvfydngkvvitdfglfsisgvlqagrredklriqngwlch
lapeiirqlspdteedklpfskhsdvfalgtiwyelharewpfktqpaeaiiwqmgtgmk
pnlsqigmgkeisdillfcwafeqeerptftklmdmleklp

Sequence, based on observed residues (ATOM records):

>d7jusb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tsiflqewdipfeqleigeligkgrfgqvyhgrwgevairlidierdnedqlkafkrevm
ayrqtrhenvvlfmgacmspphlaiitslckgrtlysvvrdakivldvnktrqiaqeivk
gmgylhakgilhkdlksknvfydngkvvitdfglfsisgvlqedklriqngwlchlapei
irqlspdteedklpfskhsdvfalgtiwyelharewpfktqpaeaiiwqmgtgmkpnlsq
igmgkeisdillfcwafeqeerptftklmdmleklp

Timeline for d7jusb_:

• d7jusb_ is new in SCOPe 2.07-stable
  
• d7jusb_ appears in the current release, SCOPe 2.08