SCOPe 2.07: Domain d7jurc_: 7jur C:

Lineage for d7jurc_ (7jur C:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Oryctolagus cuniculus [TaxId:9986] [390304] (6 PDB entries)

8. Domain d7jurc_: 7jur C: [390310]
   Other proteins in same PDB: d7jurb_
   automated match to d5hzea_
   complexed with anp, mg, qom

Details for d7jurc_

PDB Entry: 7jur, 2.82 Å

PDB Description: crystal structure of ksr2:mek1 in complex with amp-pnp, and allosteric mek inhibitor trametinib

PDB Compounds: (C:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d7jurc_:

Sequence, based on SEQRES records:

>d7jurc_ d.144.1.7 (C:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Oryctolagus cuniculus [TaxId: 9986]}
eldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklih
leikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagr
ipeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsma
nsfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcqve
gdaaetpprprtpgrplssygmdsrppmaifelldyivnepppklpsavfslefqdfvnk
cliknpaeradlkqlmvhafikrsdaeevdfagwlcstigl

Sequence, based on observed residues (ATOM records):

>d7jurc_ d.144.1.7 (C:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Oryctolagus cuniculus [TaxId: 9986]}
eldeqqrkrleafltqkqkvgelkdddfekiselvvfkvshkpsglvmarklihleikpa
irnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqil
gkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgt
rsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfpmaifelldyi
vnepppklpsavfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcs
tigl

Timeline for d7jurc_:

• d7jurc_ is new in SCOPe 2.07-stable
  
• d7jurc_ appears in the current release, SCOPe 2.08