SCOPe 2.07: Domain d7c7gb_: 7c7g B:

Lineage for d7c7gb_ (7c7g B:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (50 PDB entries)
   Uniprot P42330

8. Domain d7c7gb_: 7c7g B: [389912]
   automated match to d2fgba_
   complexed with fjr, nap

Details for d7c7gb_

PDB Entry: 7c7g, 1.86 Å

PDB Description: crystal structures of akr1c3 ternary complex with nadp+ and the chromene derivative 2j

PDB Compounds: (B:) Aldo-keto reductase family 1 member C3

SCOPe Domain Sequences for d7c7gb_:

Sequence; same for both SEQRES and ATOM records:

>d7c7gb_ c.1.7.1 (B:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpg
eelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkyk
pvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcala
kkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhy
fnsdsfashpnypysdey

Timeline for d7c7gb_:

• d7c7gb_ is new in SCOPe 2.07-stable
  
• d7c7gb_ appears in the current release, SCOPe 2.08