SCOPe 2.06: Domain d1e8wa3: 1e8w A:144-321

Lineage for d1e8wa3 (1e8w A:144-321)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Pig (Sus scrofa) [TaxId:9823] [54275] (6 PDB entries)

8. Domain d1e8wa3: 1e8w A:144-321 [37634]
   Other proteins in same PDB: d1e8wa1, d1e8wa2, d1e8wa4, d1e8wa5
   complexed with que

Details for d1e8wa3

PDB Entry: 1e8w, 2.5 Å

PDB Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine

PDB Compounds: (A:) phosphatidylinositol 3-kinase catalytic subunit

SCOPe Domain Sequences for d1e8wa3:

Sequence, based on SEQRES records:

>d1e8wa3 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa) [TaxId: 9823]}
seetlafqrqlnaligydvtdvsnvhddeleftrrrlvtprmaevagrdpklyamhpwvt
skplpeyllkkitnncvfivihrsttsqtikvsaddtpgtilqsfftkmakkkslmdipe
sqnerdfvlrvcgrdeylvgetpiknfqwvrqclkngeeihlvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d1e8wa3 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Pig (Sus scrofa) [TaxId: 9823]}
seetlafqrqlnaligydvtdvsnvhddeleftrrrlvtprmaevagrdpklyamhpwvt
skplpeyllkkitnncvfivihrsttsqtikvsaddtpgtilqsfftkmdfvlrvcgrde
ylvgetpiknfqwvrqclkngeeihlvldtppdpaldevrke

Timeline for d1e8wa3:

• d1e8wa3 first appeared (with stable ids) in SCOP 1.55
  
• d1e8wa3 appears in SCOPe 2.05
  
• d1e8wa3 appears in SCOPe 2.07
  
• d1e8wa3 appears in the current release, SCOPe 2.08