SCOPe 2.07: Domain d6u2ga_: 6u2g A:

Lineage for d6u2ga_ (6u2g A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (42 PDB entries)
   Uniprot Q02750 61-381

8. Domain d6u2ga_: 6u2g A: [373566]
   Other proteins in same PDB: d6u2gb_
   automated match to d5hzea_
   complexed with acp, mg, so4

Details for d6u2ga_

PDB Entry: 6u2g, 2.89 Å

PDB Description: braf-mek complex with amp-pcp bound to braf

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d6u2ga_:

Sequence, based on SEQRES records:

>d6u2ga_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
deqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihle
ikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagrip
eqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmans
fvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcqvegd
aaetpprprtpgrplssygmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcl
iknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq

Sequence, based on observed residues (ATOM records):

>d6u2ga_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
deqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihle
ikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagrip
eqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmans
fvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmpmaifell
dyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagw
lcstiglnq

Timeline for d6u2ga_:

• d6u2ga_ is new in SCOPe 2.07-stable
  
• d6u2ga_ appears in the current release, SCOPe 2.08