SCOPe 2.08: Domain d6ib2a1: 6ib2 A:127-417

Lineage for d6ib2a1 (6ib2 A:127-417)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d6ib2a1: 6ib2 A:127-417 [365367]
   Other proteins in same PDB: d6ib2a2
   automated match to d5y8ua_
   complexed with 862

Details for d6ib2a1

PDB Entry: 6ib2, 2.1 Å

PDB Description: the structure of mkk7 in complex with the covalent 4-amino- pyrazolopyrimidine 4a

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 7

SCOPe Domain Sequences for d6ib2a1:

Sequence, based on SEQRES records:

>d6ib2a1 d.144.1.0 (A:127-417) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qryqaeindlenlgemgsgtcgqvwkmrfrktghviavkqmrrsgnkeenkrilmdldvv
lkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperilgkmtvaivkal
yylkekhgvihrdvkpsnilldergqiklcdfgisgrlvdskaktrsagcaaymaperid
ppdptkpdydiradvwslgislvelatgqfpykkcktdfevltkvlqeeppllpghmgfs
gdfqsfvkdcltkdhrkrpkynkllehsfikryetlevdvaswfkdvmakt

Sequence, based on observed residues (ATOM records):

>d6ib2a1 d.144.1.0 (A:127-417) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qryqaeindlenlgemgqvwkmrfrktghviavkqmrrsgnkeenkrilmdldvvlkshd
cpyivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperilgkmtvaivkalyylke
khgvihrdvkpsnilldergqiklcdfaymaperidradvwslgislvelatgqfpykkc
ktdfevltkvlqeeppllpghmgfsgdfqsfvkdcltkdhrkrpkynkllehsfikryet
levdvaswfkdvmakt

Timeline for d6ib2a1:

• d6ib2a1 first appeared in SCOPe 2.07, called d6ib2a_