PDB entry 6ib2

View 6ib2 on RCSB PDB site
Description: The structure of MKK7 in complex with the covalent 4-amino-pyrazolopyrimidine 4a
Class: transferase
Keywords: MKK7, Inhibitor, Covalent, Transferase, JNK, Kinase
Deposited on 2018-11-28, released 2019-02-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-27, with a file datestamp of 2019-03-22.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14733
      • conflict (233)
    Domains in SCOPe 2.08: d6ib2a1, d6ib2a2
  • Heterogens: 862, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ib2A (A:)
mghhhhhhsakqtgyltiggqryqaeindlenlgemgsgtcgqvwkmrfrktghviavkq
mrrsgnkeenkrilmdldvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrm
qgpiperilgkmtvaivkalyylkekhgvihrdvkpsnilldergqiklcdfgisgrlvd
skaktrsagcaaymaperidppdptkpdydiradvwslgislvelatgqfpykkcktdfe
vltkvlqeeppllpghmgfsgdfqsfvkdcltkdhrkrpkynkllehsfikryetlevdv
aswfkdvmaktesprtsg

    Sequence, based on observed residues (ATOM records): (download) 
    >6ib2A (A:)
qtgyltiggqryqaeindlenlgemgqvwkmrfrktghviavkqmrrsgnkeenkrilmd
ldvvlkshdcpyivqcfgtfitntdvfiamelmgtcaeklkkrmqgpiperilgkmtvai
vkalyylkekhgvihrdvkpsnilldergqiklcdfaymaperidradvwslgislvela
tgqfpykkcktdfevltkvlqeeppllpghmgfsgdfqsfvkdcltkdhrkrpkynklle
hsfikryetlevdvaswfkdvmakt