SCOP 1.71: Domain d1cw4a_: 1cw4 A:

Lineage for d1cw4a_ (1cw4 A:)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins)
   the active site is between the two identical subunits

6. Protein Isocitrate dehydrogenase, ICDH [53668] (2 species)

7. Species Escherichia coli [TaxId:562] [53669] (26 PDB entries)

8. Domain d1cw4a_: 1cw4 A: [35068]
   complexed with akg, mn, so4; mutant

Details for d1cw4a_

PDB Entry: 1cw4, 2.1 Å

PDB Description: crystal structure of k230m isocitrate dehydrogenase in complex with alpha-ketoglutarate

SCOP Domain Sequences for d1cw4a_:

Sequence; same for both SEQRES and ATOM records:

>d1cw4a_ c.77.1.1 (A:) Isocitrate dehydrogenase, ICDH {Escherichia coli}
eskvvvpaqgkkitlqngklnvpenpiipyiegdgigvdvtpamlkvvdaavekaykger
kiswmeiytgekstqvygqdvwlpaetldlireyrvaikgplttpvgggirslnvalrqe
ldlyiclrpvryyqgtpspvkhpeltdmvifrensediyagiewkadsadaekvikflre
emgvkkirfpehcgigikpcseegtkrlvraaieyaiandrdsvtlvhmgnimkftegaf
kdwgyqlareefggelidggpwlkvknpntgkeivikdviadaflqqillrpaeydviac
mnlngdyisdalaaqvggigiapganigdecalfeathgtapkyagqdkvnpgsiilsae
mmlrhmgwteaadlivkgmegainaktvtydferlmdgakllkcsefgdaiienm

Timeline for d1cw4a_:

• d1cw4a_ first appeared (with stable ids) in SCOP 1.55
  
• d1cw4a_ appears in SCOP 1.69
  
• d1cw4a_ appears in SCOP 1.73
  
• d1cw4a_ appears in the current release, SCOPe 2.08