SCOP 1.67: Domain d8dfr__: 8dfr -

Lineage for d8dfr__ (8dfr -)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.71: Dihydrofolate reductases [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductases [53597] (1 family)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (4 species)

7. Species Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries)

8. Domain d8dfr__: 8dfr - [34895]
   complexed with ca, ndp

Details for d8dfr__

PDB Entry: 8dfr, 1.7 Å

PDB Description: refined crystal structures of chicken liver dihydrofolate reductase. 3 angstroms apo-enzyme and 1.7 angstroms nadph holo-enzyme complex

SCOP Domain Sequences for d8dfr__:

Sequence; same for both SEQRES and ATOM records:

>d8dfr__ c.71.1.1 (-) Dihydrofolate reductases, eukaryotic type {Chicken (Gallus gallus)}
vrslnsivavcqnmgigkdgnlpwpplrneykyfqrmtstshvegkqnavimgkktwfsi
peknrplkdrinivlsrelkeapkgahylskslddalalldspelkskvdmvwivggtav
ykaamekpinhrlfvtrilhefesdtffpeidykdfkllteypgvpadiqeedgiqykfe
vyqksv

Timeline for d8dfr__:

• d8dfr__ first appeared (with stable ids) in SCOP 1.55
  
• d8dfr__ appears in SCOP 1.65
  
• d8dfr__ appears in SCOP 1.69
  
• d8dfr__ appears in the current release, SCOPe 2.08, called d8dfra_