SCOPe 2.06: Domain d5v2ib_: 5v2i B:

Lineage for d5v2ib_ (5v2i B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families)
   N-terminal residue provides two catalytic groups, nucleophile and proton donor

5. Family d.153.1.5: (Glycosyl)asparaginase [56261] (2 proteins)
   automatically mapped to Pfam PF01112

6. Protein Glycosylasparaginase (aspartylglucosaminidase, AGA) [56262] (5 species)
   the precursor chain is cleaved onto 2 fragments by autoproteolysis

7. Species Elizabethkingia meningoseptica [TaxId:238] [334312] (1 PDB entry)

8. Domain d5v2ib_: 5v2i B: [334405]
   automated match to d4r4yb_
   mutant

Details for d5v2ib_

PDB Entry: 5v2i, 1.83 Å

PDB Description: crystal structure of a mutant glycosylasparaginase (g172d) that causes the genetic disease aspartylglucosaminuria

PDB Compounds: (B:) glycosylasparaginase

SCOPe Domain Sequences for d5v2ib_:

Sequence, based on SEQRES records:

>d5v2ib_ d.153.1.5 (B:) Glycosylasparaginase (aspartylglucosaminidase, AGA) {Elizabethkingia meningoseptica [TaxId: 238]}
ttnkpivlstwnfglhanveawkvlskggkaldavekgvrlveddptersvgyggrpdrd
grvtldacimdenynigsvacmehiknpisvaravmektphvmlvgdgalefalsqgfkk
enlltaesekewkewlktsqykpivnienhdtigmialdaqgnlsgacttsdmaykmhgr
vgdspiigaglfvdneigaatatghgeevirtvgthlvvelmnqgrtpqqackeaveriv
kivnrrgknlkdiqvgfialnkkgeygayciqdgfnfavhdqkgnrletpgfalk

Sequence, based on observed residues (ATOM records):

>d5v2ib_ d.153.1.5 (B:) Glycosylasparaginase (aspartylglucosaminidase, AGA) {Elizabethkingia meningoseptica [TaxId: 238]}
ttnkpivlstwnfglhanveawkvlskggkaldavekgvrlvedgrpdrdgrvtldacim
denynigsvacmehiknpisvaravmektphvmlvgdgalefalsqgfkkenlltaesek
ewkewltigmialdaqgnlsgacttsdmaykmhgrvgdspiigaglfvdneigaatatgh
geevirtvgthlvvelmnqgrtpqqackeaverivkivnrrgknlkdiqvgfialnkkge
ygayciqdgfnfavhdqkgnrletpgfalk

Timeline for d5v2ib_:

• d5v2ib_ is new in SCOPe 2.06-stable
  
• d5v2ib_ appears in SCOPe 2.07
  
• d5v2ib_ appears in the current release, SCOPe 2.08