SCOPe 2.06: Domain d5fdlb_: 5fdl B:

Lineage for d5fdlb_ (5fdl B:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (4 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (172 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d5fdlb_: 5fdl B: [314423]
   Other proteins in same PDB: d5fdla2
   automated match to d1s1tb_
   complexed with 5dv; mutant

Details for d5fdlb_

PDB Entry: 5fdl, 3.1 Å

PDB Description: crystal structure of k103n/y181c mutant hiv-1 reverse transcriptase (rt) in complex with idx899

PDB Compounds: (B:) p66 Reverse transcriptase

SCOPe Domain Sequences for d5fdlb_:

Sequence, based on SEQRES records:

>d5fdlb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvpldedfrk
ytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivicqymdd
lyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivl
pekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaen
reilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvk
qlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklw
yq

Sequence, based on observed residues (ATOM records):

>d5fdlb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwephpaglkknksvtvldvgdayfsvpldedfrkytaft
ipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivicqymddlyvgs
dleigqhrtkieelrqhllrwgltelhpdkwtvqpivlpekdswtvndiqklvgklnwas
qiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliae
iqkqgqgqwtyqiyqepfknlktgkyarhtndvkqlteavqkittesiviwgktpkfklp
iqketwetwwteywqatwipewefvntpplvklwyq

Timeline for d5fdlb_:

• d5fdlb_ is new in SCOPe 2.06-stable
  
• d5fdlb_ appears in SCOPe 2.07
  
• d5fdlb_ appears in the current release, SCOPe 2.08