SCOPe 2.08: Domain d4gpqa1: 4gpq A:2-230

Lineage for d4gpqa1 (4gpq A:2-230)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.389: Menin N-terminal domain-like [310556] (1 superfamily)
   Some structural similarity to cysteine proteinases (d.3.1.4) noted in PubMed 22327296

4. Superfamily d.389.1: Menin N-terminal domain-like [310582] (1 family)
   Pfam PF05053

5. Family d.389.1.1: Menin N-terminal domain-like [310623] (2 proteins)

6. Protein Menin N-terminal domain [310724] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [310972] (34 PDB entries)

8. Domain d4gpqa1: 4gpq A:2-230 [307460]
   Other proteins in same PDB: d4gpqa2
   automated match to d3u85a1
   complexed with epe, peg, pg4

Details for d4gpqa1

PDB Entry: 4gpq, 1.46 Å

PDB Description: Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

PDB Compounds: (A:) Menin

SCOPe Domain Sequences for d4gpqa1:

Sequence; same for both SEQRES and ATOM records:

>d4gpqa1 d.389.1.1 (A:2-230) Menin N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
glkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrvgltyfpva
dlsiiaalyarftaqirgavdlslypreggvssrelvkkvsdviwnslsrsyfkdrahiq
slfsfitgtkldssgvafavvgacqalglrdvhlalsedhawvvfgpngeqtaevtwhgk
gnedrrgqtvnagvaerswlylkgsymrc

Timeline for d4gpqa1:

• d4gpqa1 first appeared in SCOPe 2.06
  
• d4gpqa1 appears in SCOPe 2.07