SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family d.3.1.4: Transglutaminase core

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2154577Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 2154578Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 2155058Family d.3.1.4: Transglutaminase core [54044] (3 protein domains)

Protein Domains:

  1. 2155059Peptide:N-glycanase 1, PNG1 [142852] (2 species)
    1. 2155060Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [142853] (1 PDB entry)
      Uniprot Q02890 8-327
    2. 2155062Species Mouse (Mus musculus) [TaxId:10090] [159840] (1 PDB entry)
      Uniprot Q9JI78 164-450
  2. 2155064Transglutaminase catalytic domain [54045] (4 species)
    1. 2155065Species Human (Homo sapiens), blood isozyme [TaxId:9606] [54046] (9 PDB entries)
      Coagulation factor XIII
    2. 2155084Species Human (Homo sapiens), TGase E3 [TaxId:9606] [75334] (9 PDB entries)
    3. 2155102Species Human (Homo sapiens), tissue isozyme [TaxId:9606] [75333] (4 PDB entries)
      GDP-binding protein
    4. 2155116Species Red sea bream (Chrysophrys major) [TaxId:143350] [64204] (1 PDB entry)
  3. 2155118automated matches [190634] (3 species)
    not a true protein
    1. 2155119Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [188107] (1 PDB entry)
    2. 2155121Species Human (Homo sapiens) [TaxId:9606] [256347] (1 PDB entry)
    3. 2155124Species Mouse (Mus musculus) [TaxId:10090] [187686] (1 PDB entry)

More info for Family d.3.1.4: Transglutaminase core

Timeline for Family d.3.1.4: Transglutaminase core: