SCOP 1.73: Domain d1abna_: 1abn A:

Lineage for d1abna_ (1abn A:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (1 family)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (15 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (53 PDB entries)

8. Domain d1abna_: 1abn A: [28683]
   complexed with ndp; mutant

Details for d1abna_

PDB Entry: 1abn, 2.4 Å

PDB Description: the crystal structure of the aldose reductase nadph binary complex

PDB Compounds: (A:) aldose reductase

SCOP Domain Sequences for d1abna_:

Sequence, based on SEQRES records:

>d1abna_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
srlllnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqek
lreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgkef
fpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpav
nqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakhn
kttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvsall
sctshkdypfheef

Sequence, based on observed residues (ATOM records):

>d1abna_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
srlllnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqek
lreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgkef
fpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpav
nqiechpyltqekliqycqskgivvtaysplgspddprikaiaakhnkttaqvlirfpmq
rnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvsallsctshkdypfhee
f

Timeline for d1abna_:

• d1abna_ first appeared (with stable ids) in SCOP 1.55, called d1abn__
  
• d1abna_ was called d1abn__ in SCOP 1.71
  
• d1abna_ appears in SCOP 1.75
  
• d1abna_ appears in the current release, SCOPe 2.08