SCOP 1.75: Domain d2trsa_: 2trs A:

Lineage for d2trsa_ (2trs A:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (6 families)

5. Family c.1.2.4: Tryptophan biosynthesis enzymes [51381] (3 proteins)

6. Protein Trp synthase alpha-subunit [51388] (5 species)

7. Species Salmonella typhimurium [TaxId:90371] [51389] (49 PDB entries)

8. Domain d2trsa_: 2trs A: [28577]
   Other proteins in same PDB: d2trsb_
   complexed with ipl, na, pls; mutant

Details for d2trsa_

PDB Entry: 2trs, 2.04 Å

PDB Description: crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes

PDB Compounds: (A:) tryptophan synthase

SCOP Domain Sequences for d2trsa_:

Sequence, based on SEQRES records:

>d2trsa_ c.1.2.4 (A:) Trp synthase alpha-subunit {Salmonella typhimurium [TaxId: 90371]}
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrs
gvtgaenrgalplhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivki
ieknlaspkqmlaelrsfvsamkaasra

Sequence, based on observed residues (ATOM records):

>d2trsa_ c.1.2.4 (A:) Trp synthase alpha-subunit {Salmonella typhimurium [TaxId: 90371]}
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrs
gvtgaenhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivkiieknla
spkqmlaelrsfvsamkaasra

Timeline for d2trsa_:

• d2trsa_ first appeared (with stable ids) in SCOP 1.55
  
• d2trsa_ appears in SCOP 1.73
  
• d2trsa_ appears in SCOPe 2.01
  
• d2trsa_ appears in the current release, SCOPe 2.08