SCOPe 2.07: Domain d4z2wa_: 4z2w A:

Lineage for d4z2wa_ (4z2w A:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (1 protein)

6. Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82196] (34 PDB entries)

8. Domain d4z2wa_: 4z2w A: [280555]
   automated match to d2xuma_
   complexed with akg, fe, peg, so4

Details for d4z2wa_

PDB Entry: 4z2w, 2.5 Å

PDB Description: factor inhibiting hif in complex with fe, and alpha-ketoglutarate

PDB Compounds: (A:) Hypoxia-inducible factor 1-alpha inhibitor

SCOPe Domain Sequences for d4z2wa_:

Sequence; same for both SEQRES and ATOM records:

>d4z2wa_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
vasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdtn
lvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhef
veklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnlll
igmegnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnpd
yerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkriey
plkahqkvaimrniekmlgealgnpqevgpllntmikgryn

Timeline for d4z2wa_:

• d4z2wa_ first appeared in SCOPe 2.05
  
• d4z2wa_ appears in SCOPe 2.06
  
• d4z2wa_ appears in the current release, SCOPe 2.08